Comparison of anti-inflammatory efficacy of lercanidipine and Tanacetum parthenium with indomethacin in rats

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dc.contributor.authorRajdan, Neerajen_US
dc.contributor.authorJain, Atulen_US
dc.contributor.authorDixit, Aloken_US
dc.contributor.authorSingh, Chandra Veeren_US
dc.date.accessioned2020-04-23T07:50:00Z
dc.date.available2020-04-23T07:50:00Z
dc.date.issued2018-06
dc.description.abstractBackground: Inflammation can be classified as either acute or chronic. NSAIDs are the most commonly prescribed drugs worldwide, and mostly have adverse effects. Lercanidipine a CCB of (DHPs) blocks the mediators of inflammation and has additional anti-inflammatory potential. Tanacetum parthenium (Feverfew) extracts have also shown its anti-inflammatory effects in experimental studies. It was decided to study anti-inflammatory effects of Lercanidipine and Tanacetum parthenium which was compared with Indomethacin. The present study was aimed to evaluate and compare the anti-inflammatory effect of lercanidipine and Tanacetum parthenium with Indomethacin in rats.Methods: The study was conducted in the department of Pharmacology UPUMS, Saifai after getting approval from IAEC.A total of 24 animals divided into 4 groups of six (n=6) animals each group were used, and the anti-inflammatory effects of both drugs were evaluated by Carrageenan-induced Paw Edema Model by digital Plethysmometer in rats, drug administration was with the same frequency.Results: The result of the present study had shown that lercanidipine produced anti-inflammatory effect compared to Indomethacin, while its efficacy in reducing paw edema was better at 1st hour, 48 and 72 hours while at 2nd hour and 3rd hour Indomethacin had better efficacy. Tanacetum parthenium also decreased paw edema at 2nd, 3rd, 48 and 72 hour while at 1st hour no effect was seen. However, at 72 hours, shown good efficacy compared to lercanidipine and Indomethacin.Conclusions: Lercanidipine could be a promising anti-inflammatory drug in reducing the inflammation and edema. However, herbal drug (Tanacetum parthenium) has shown anti- inflammatory efficacy when compared with Indomethacin. Both drugs were found safe during our study.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Uttar Pradesh University of Medical Sciences, Saifai, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Dr. RML Institute of Medical Sciences, Lakhnow, Uttar Pradesh, Indiaen_US
dc.identifier.citationRajdan Neeraj, Jain Atul, Dixit Alok, Singh Chandra Veer. Comparison of anti-inflammatory efficacy of lercanidipine and Tanacetum parthenium with indomethacin in rats. International Journal of Basic & Clinical Pharmacology. 2018 Jun; 7(6): 1072-1077en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199733
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber6en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20182015en_US
dc.subjectCarrageenanen_US
dc.subjectInflammationen_US
dc.subjectLercanidipineen_US
dc.subjectTanacetum partheniumen_US
dc.subjectPlethysmometeren_US
dc.titleComparison of anti-inflammatory efficacy of lercanidipine and Tanacetum parthenium with indomethacin in ratsen_US
dc.typeJournal Articleen_US
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