Molecular cytogenetic analysis of urothelial carcinomas using urine samples.

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dc.contributor.authorAyati, Men_US
dc.contributor.authorTousi, V Najjaranen_US
dc.contributor.authorSabokba, Ten_US
dc.contributor.authorVaziri-Nasab, Hen_US
dc.contributor.authorMehrkhani, Fen_US
dc.contributor.authorJamshidian, Hen_US
dc.contributor.authorDastan, Jen_US
dc.contributor.authorMosavi-Jarrahi, A Ren_US
dc.contributor.authorGhaffari, S Ren_US
dc.date.accessioned2009-05-27T17:51:34Z
dc.date.available2009-05-27T17:51:34Z
dc.date.issued2008-10-05en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractUrinary cells obtained from voided urine specimens of 46 patients with urothelial carcinomas (UCs) and 10 normal individuals were analyzed with 3 different centromeric fluorescence in situ hybridization (FISH) probes. The overall sensitivity of cytology was 48.9% compared to 95.7%with the FISH technique. The minimum values were found for stage Ta and grade 1 (90.5 and 89.4) and sensitivity of FISH in other stages and grades was 100%. Chromosome 3 demonstrated the most frequent chromosomal abnormality in all samples (43%), followed by chromosome 17 (32%) and chromosome 7 (25%). There was a statistically significant association between the number of cell abnormalities in chromosome 17 and the tumour stage (p value=0.02). No relationship was found between the type of chromosomal abnormality and grade. Thus feasibility and reliability of a FISH based approach was confirmed for detection of UC in urine samples.en_US
dc.description.affiliationDepartment of Urooncology, Imam Khomeini Hospital, Tehran, Iran.en_US
dc.identifier.citationAyati M, Tousi VN, Sabokba T, Vaziri-Nasab H, Mehrkhani F, Jamshidian H, Dastan J, Mosavi-Jarrahi AR, Ghaffari SR. Molecular cytogenetic analysis of urothelial carcinomas using urine samples. Asian Pacific Journal of Cancer Prevention. 2008 Oct-Dec; 9(4): 687-90en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/38036
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.titleMolecular cytogenetic analysis of urothelial carcinomas using urine samples.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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