Predictors of severity factors associated with severe scrub typhus among children in a tertiary care hospital

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dc.contributor.authorPanda, Subhasmitaen_US
dc.contributor.authorPanda, Kalpanaen_US
dc.contributor.authorSwain, Subrat Kumaren_US
dc.contributor.authorGupta, Medhaen_US
dc.contributor.authorSarangi, Rachitaen_US
dc.date.accessioned2025-08-13T09:35:50Z
dc.date.available2025-08-13T09:35:50Z
dc.date.issued2025-06
dc.description.abstractBackground & objectives: Scrub typhus is an acute febrile zoonotic disease caused by the obligate intracellular gram-negative bacteria Orientia tsutsugamushi. Growing data over the last few years from the Indian subcontinent suggest that it is one of the most widespread but under-reported diseases. This study aimed to document the clinical and paraclinical profiles and evaluate complications of scrub typhus in severe and non-severe pediatric age groups. Methods: A prospective observational study was conducted in pediatric patients. Frequency, mean, percentage and standard deviation were included in the descriptive statistical analysis calculations. Multivariate analysis was conducted to predict the severity factor. Results: A total of 189 patients met the eligibility criteria and were included in the final analysis. The mean and standard deviation (mean ± SD) age of the cohort was 5.54 ± 3.9 years, with a male predominance of 68.2%. The mean ± SD duration of fever was 6.64 ± 1.43 days. Patients with severe scrub typhus experienced complications including hepatic involvement (42, 64.6%), respiratory distress (23, 46.1%), neurological involvement (14, 24.6%), acute kidney injury (10, 15.4%), myocarditis (9, 13.8%), and (16, 24.6%) have multi-organ dysfunction. Patients with raised transaminases (> 180 IU/L) have a 3.7 to 4.1 times greater chance of developing severity. Thrombocytopenia is found to be another independent predictor of severe scrub typhus. Interpretation & conclusion: Clinical signs of hepatomegaly, skin rash, and lymphadenopathy were significant predictors of severity. Delay in treatment is a key contributor to the severity of pediatric scrub typhus.en_US
dc.identifier.affiliationsDepartment of Pediatrics, IMS and SUM Hospital, Siksha ‘O ’ Anusandhan (deemed to be) University, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, IMS and SUM Hospital, Siksha ‘O ’ Anusandhan (deemed to be) University, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsMedical Research Laboratory, IMS and SUM Hospital, Siksha ‘O ’ Anusandhan (deemed to be) University, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, IMS and SUM Hospital, Siksha ‘O ’ Anusandhan (deemed to be) University, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, IMS and SUM Hospital, Siksha ‘O ’ Anusandhan (deemed to be) University, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.citationPanda Subhasmita, Panda Kalpana, Swain Subrat Kumar, Gupta Medha, Sarangi Rachitaa. Predictors of severity factors associated with severe scrub typhus among children in a tertiary care hospital. Journal of Vector Borne Diseases . 2025 Jun; 62(2): 165-171en_US
dc.identifier.issn0972-9062
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252549
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber2en_US
dc.relation.volume62en_US
dc.source.urihttps://doi.org/10.4103/JVBD.JVBD_56_24https://creativecommons.org/licenses/by-nc-sa/4.0en_US
dc.subjectScrub typhusen_US
dc.subjectComplicationsen_US
dc.subjectPediatric populationen_US
dc.subjectOrientia tsutsugamushien_US
dc.titlePredictors of severity factors associated with severe scrub typhus among children in a tertiary care hospitalen_US
dc.typeJournal Articleen_US
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