Microcalorimetric studies on cell survival and repair after UV induced damage.

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dc.contributor.authorSharma, Men_US
dc.contributor.authorJain, Ven_US
dc.date.accessioned2009-05-28T12:56:43Z
dc.date.available2009-05-28T12:56:43Z
dc.date.issued1990-08-01en_US
dc.description.abstractRate of heat production during cell proliferation following UV-irradiation of respiratory-deficient yeast cells was measured as a function of time (p-t curve) in a batch microcalorimeter. Following observations were made: (a) All growing cell cultures showed 3 distinct phases of heat production namely lag, exponential and declining phases of rate of heat production. (b) Duration of the lag phase is inversely proportional to the number of cells capable of proliferation. (c) After UV-irradiation, lag phase increased in a dose dependent manner. (d) Liquid-holding reactivation increased the surviving fraction and reduced the lag phase in p-t curves. Presence of 2-deoxy-D-glucose during liquid-holding prevented the reduction in lag phase due to the inhibition of repair processes.en_US
dc.description.affiliationDepartment of Biophysics, National Institute of Mental Health & Neuro Sciences, Bangalore, India.en_US
dc.identifier.citationSharma M, Jain V. Microcalorimetric studies on cell survival and repair after UV induced damage. Indian Journal of Experimental Biology. 1990 Aug; 28(8): 762-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58758
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshCalorimetryen_US
dc.subject.meshCell Division --drug effectsen_US
dc.subject.meshDeoxyglucose --pharmacologyen_US
dc.subject.meshEnergy Metabolism --drug effectsen_US
dc.subject.meshSaccharomyces cerevisiae --drug effectsen_US
dc.subject.meshUltraviolet Raysen_US
dc.titleMicrocalorimetric studies on cell survival and repair after UV induced damage.en_US
dc.typeJournal Articleen_US
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