Effect of Tinospora cordifolia as an add - on therapy on the blood glucose levels of patients with Type 2 diabetes.
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Date
2015-05
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Abstract
Background: Type 2 diabetes is a fast growing epidemic affecting people globally.
Good glycemic control helps in reducing the risk of macro and microvascular
complications in diabetics. Alternative medicines have been used since ancient
times in India to achieve good glycemic control. Tinospora cordifolia (Tc) is a well
reported plant possessing anti-diabetic property. Therefore, we undertook this study to
evaluate the effectivity of Tc in reducing the blood glucose levels of Type 2 diabetic
patients in the form of add-on therapy.
Methods: In the present study, we enrolled 100 Type 2 diabetic patients who met
our inclusion criteria. These patients were then randomly divided into two Groups,
A and B. Patients in Group A were treated as controls and they continued with their
anti-diabetic medications. In Group B, Tc was added to the conventional treatment
at a dose of 500 mg 3 times daily along with meals. The fasting and postprandial
blood glucose levels and glycosylated hemoglobin (HbA1c) were recorded baseline
and after 6 months.
Results: During the course of study, we observed a decrease in the fasting,
postprandial, and HbA1c levels of the patients. However, this decrease was found
to be more statistically significant (p≤0.005) in Group B.
Conclusion: The results obtained from the present study conclude that Tc, when
given in the form of add-on therapy, was found to be synergistic and effective in the
better management of Type 2 diabetes. The drug was well tolerated by the patients
and no adverse drug event was recorded.
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Keywords
Type 2 diabetes, Tinospora cordifolia, Oral hypoglycemic agents
Citation
Mishra Saumya, Verma Narsingh, Bhattacharya Sandeep, Usman Kauser, Himanshu D, Singh Prerana, Anjum B, Verma Neera. Effect of Tinospora cordifolia as an add - on therapy on the blood glucose levels of patients with Type 2 diabetes. International Journal of Basic & Clinical Pharmacology. 2015 May-Jun; 4(3): 537-541.