The Essentials of Biochemistry of the Proteins as Related to Alzheimer’s Disease: A Review

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dc.contributor.authorPrasad, A. S. V.en_US
dc.date.accessioned2020-05-05T07:04:51Z
dc.date.available2020-05-05T07:04:51Z
dc.date.issued2020-02
dc.description.abstractAmyloid plaques and Tau tangles, constitute the pathological hallmarks of the brains of the patients suffering from Alzheimer’s disease. They are identified as far back as 1996 by Alois Alzheimer, a German psychiatrist and neuropathologist, but till this date, how they produce neuronal death remained an enigma. The amyloid cascade theory held its sway until recent times until the emphasis is shifted to the metabolites of amyloid Beta precursor protein (APP). Several metabolites of APP are formed depending on by which pathway, the APP is metabolized, either by the non - amyloidogenic pathway (forming ? - C terminal fragment - CTF? / C83 and the N - terminal fragment sAPP? / P3 and the APP intracellular domain AICD). Or amyloidogenic pathways. ( Forming extracellular A? and APP intracellular domain - AICD). The hyperphosphorylation is held responsible for the tau protein tangles. The over activity of the tau kinases or the failure of inhibition by the tau phosphatases i s implicated, in tau tangle deposits. These biochemical aspects of AD assumed importance in connection with the interventional therapeutic strategies that are developed in the years bygone, as well as those still are in the developing stage. In keeping with this fact, it is attempted to review the essentials of the biochemical aspects of the involved proteins, as related to AD, in this articleen_US
dc.identifier.affiliationsDepartment of Internal Medicine, Gandhi Institute of Technology and Management (G.I.T.A.M), Rushikonda, Visakhapatnam, Indiaen_US
dc.identifier.citationPrasad A. S. V. . The Essentials of Biochemistry of the Proteins as Related to Alzheimer’s Disease: A Review . International Journal of Biochemistry Research & Review. 2020 Feb; 29(1): 34-49en_US
dc.identifier.issn2231-086X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200778
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber1en_US
dc.relation.volume29en_US
dc.source.urihttps://doi.org/10.9734/IJBCRR/2020/v29i130163en_US
dc.subjectAmyloid Precursor Protein(APP)en_US
dc.subjectamyloidbetaen_US
dc.subjectamyloidplaquesen_US
dc.subjecttauproteinen_US
dc.subjectamyloid casca detheoryen_US
dc.subjectamyloidogenic pathwayen_US
dc.subjectnon-amyloidogenic pathwayen_US
dc.subjectsecretasesen_US
dc.titleThe Essentials of Biochemistry of the Proteins as Related to Alzheimer’s Disease: A Reviewen_US
dc.typeJournal Articleen_US
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