Synthesis of multiple biologically active 1, 2-dihydro-pyrimido [1, 2-A]-benzimidazole-3- carbonitrile.
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Date
2010-08
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Abstract
A variety of 1,2-dihydropyrimido-[1,2-a]-benzimidazole-3-carbonitrile
derivatives were synthesized under microwave irradiation using water and acetonitril as
solvent system. All the compounds were tested in vitro for α-glucosidase inhibitory and
DPPH free radical scavenging activity. 4-Amino-2-(4-flourophenyl)-1,2-dihydropyrimido
[1,2-a]-benzimidazole-3-carbonitrile (4c) was found to be a potent intestinal α-
glucosidase inhibi tory activity (IC50; 91μM) along with moderate DPPH scavenging
property. This compound was further evaluated for cytotoxicity activity against HT-29
colon cancer cell line. The IC50 value for its cytotoxicity activity was found to be 662
μM.
Description
Keywords
Benzimidazole carbonitriles, α-glucosidase, free radical scavenger, cytotoxic
Citation
Kumbhare Ravindra M, Kosurkar Umesh, Kumar K Vijay, Dadmal Tulshiram, Tiwari A K. Synthesis of multiple biologically active 1, 2-dihydro-pyrimido [1, 2-A]-benzimidazole-3- carbonitrile. International Journal of Applied Biology and Pharmaceutical Technology. 2010 Aug-Oct; 1(2): 729-735.