14-3-3 proteins mediate the localization of Centrin2 to centrosome

Simple item page
dc.contributor.authorBoseh, Arunabhaen_US
dc.contributor.authorDalal, Sorab Nen_US
dc.date.accessioned2020-11-18T10:14:27Z
dc.date.available2020-11-18T10:14:27Z
dc.date.issued2019-06
dc.description.abstract14-3-3e and 14-3-3c localize to the centrosome and regulate centrosome duplication, by inhibiting cdc25C function. As14-3-3c and 14-3-3e form a complex with centrosomal proteins, we asked if this ability was required to regulate centrosomeduplication. The results in this report demonstrate that 14-3-3e and 14-3-3c form a complex with Centrin2 and that thebinding site is located in the N-terminal EF hand in Centrin2, EF1. A Centrin2 mutant that does not form a complex with14-3-3 proteins displays a punctate cytoplasmic localization and does not localize to the centrosome. These results suggestthat in addition to negatively regulating centrosome duplication as previously reported, 14-3-3 proteins might also berequired for centriole biogenesis by regulating the localization of Centrin2 at the centrosome.en_US
dc.identifier.affiliationsKS230, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar Node, Navi Mumbai 410210, India Homi Bhabha National Institute, Training School complex, Anushakti Nagar, Mumbai 400085, Indiaen_US
dc.identifier.affiliationsKS230, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar Node, Navi Mumbai 410210, India Homi Bhabha National Institute, Training School complex, Anushakti Nagar, Mumbai 400085, Indiaen_US
dc.identifier.citationBoseh Arunabha, Dalal Sorab N. 14-3-3 proteins mediate the localization of Centrin2 to centrosome. Journal of Biosciences. 2019 Jun; 44(2): 1-10en_US
dc.identifier.issn0250-5991
dc.identifier.issn0973-7138
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/214382
dc.languageenen_US
dc.publisherIndian Academy of Sciencesen_US
dc.relation.issuenumber2en_US
dc.relation.volume44en_US
dc.source.urihttps://dx.doi.org//10..1007/s12038-019-9867-5en_US
dc.subjectCentrosomeen_US
dc.subjectcentrioleen_US
dc.subjectCentrin2en_US
dc.subject14-3-3en_US
dc.title14-3-3 proteins mediate the localization of Centrin2 to centrosomeen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
jbsc2019v44n2pp1.pdf
Size:
1.73 MB
Format:
Adobe Portable Document Format
Download
Collections
Journal of Biosciences