Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trial

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dc.contributor.authorBhardwaj, Pankajen_US
dc.contributor.authorGanapathy, Kalaiselvanen_US
dc.contributor.authorPathania, Monikaen_US
dc.contributor.authorNaveen, K.H.en_US
dc.contributor.authorCharan, Jaykaranen_US
dc.contributor.authorDutta, Siddharthaen_US
dc.contributor.authorGadepalli, Ravisekharen_US
dc.contributor.authorSrinivasan, Srikanthen_US
dc.contributor.authorGupta, Manoj Kumaren_US
dc.contributor.authorGoel, Akhil D.en_US
dc.contributor.authorMidha, Nareshen_US
dc.contributor.authorKumar, Bharaten_US
dc.contributor.authorSharma, Meenakshien_US
dc.contributor.authorSharma, Praveenen_US
dc.contributor.authorBanerjee, Mithuen_US
dc.contributor.authorMitra, Prasenjiten_US
dc.contributor.authorMisra, Sanjeeven_US
dc.contributor.authorV, Vinayagamoorthyen_US
dc.contributor.authorSubramaniant, Girijaen_US
dc.contributor.authorR, Praveenen_US
dc.contributor.authorDhar, Minakshien_US
dc.contributor.authorSaxena, Vartikaen_US
dc.contributor.authorDhamija, Puneeten_US
dc.contributor.authorSingh, Archanaen_US
dc.contributor.authorSubramanian, Saumyaen_US
dc.contributor.authorKanchibhotla, Divyaen_US
dc.date.accessioned2024-11-30T08:13:08Z
dc.date.available2024-11-30T08:13:08Z
dc.date.issued2023-11
dc.description.abstractBackground: Medicines in indigenous systems such as Ayurveda have strong antimicrobial activity but double- blind randomized control trials are infrequent in this system of medicine. The efficacy of a new ayurvedic formulation was evaluated during the pandemic. Methods: 150 mild-moderate COVID-19 patients were enrolled and randomized in 1:1 to NAOQ19 and placebo group. RT-PCR was done on Day 3, 5 and 7. CBC, CRP, LFT, and KFT were assessed at baseline and exit. Duration of hospital stay was noted and clinical assessment was also performed. Result: The results demonstrated more people turning RT-PCR negative in the NAOQ19 group compared to the placebo group on day 3 (p-value = 0.033). The mean time duration to turn RT-PCR negative was significantly lower in the NAOQ19 group (4.6 days) compared to placebo group (5.2 days) (p-value = 0.018). There was significant reduction in hospital stay among patients in the NAOQ19 arm who were discharged earlier (5.6 days) compared to placebo group (6.4 days) (p-value = 0.046). Patients in NAOQ19 arm did not show any adverse life- threatening events. Conclusion: The ayurvedic preparation given along with standard of care therapy reduced the duration of hospital stay and there was earlier conversion to RT-PCR negative.The integrated approach can help to reduce patient workload in the hospitals as well as limit the transmission of the virus in the community.en_US
dc.identifier.affiliationsDepartment of CMFM, AIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsDepartment of Community Medicine, SMVMCH Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, AIIMS Rishikesh, Indiaen_US
dc.identifier.affiliationsDepartment of CMFM, AIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, AIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, AIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, AIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsDepartment of CMFM, AIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsDepartment of CMFM, AIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsDepartment of CMFM, AIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsDepartment of General Medicine, AIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsDepartment of General Medicine, AIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsDepartment of AYUSH, AIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, AIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, AIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, AIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsAIIMS Jodhpur, Indiaen_US
dc.identifier.affiliationsDepartment of Community Medicine, SMVMCH Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of General Medicine, SMVMCH Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Respiratory Medicine, SMVMCH Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, AIIMS Rishikesh, Indiaen_US
dc.identifier.affiliationsDepartment of CFM &AYUSH, AIIMS Rishikesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, AIIMS Rishikesh, Indiaen_US
dc.identifier.affiliationsDepartment of Shalya Tantra, AIIMS Rishikesh, Indiaen_US
dc.identifier.affiliationsSri Sri Institute for Advanced Research, Indiaen_US
dc.identifier.affiliationsSri Sri Institute for Advanced Research, Indiaen_US
dc.identifier.citationBhardwaj Pankaj, Ganapathy Kalaiselvan, Pathania Monika, Naveen K.H., Charan Jaykaran, Dutta Siddhartha, Gadepalli Ravisekhar, Srinivasan Srikanth, Gupta Manoj Kumar, Goel Akhil D., Midha Naresh, Kumar Bharat, Sharma Meenakshi, Sharma Praveen, Banerjee Mithu, Mitra Prasenjit, Misra Sanjeev, V Vinayagamoorthy, Subramaniant Girija, R Praveen, Dhar Minakshi, Saxena Vartika, Dhamija Puneet, Singh Archana, Subramanian Saumya, Kanchibhotla Divya . Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trial. Journal of Ayurveda and Integrative Medicine. 2023 Nov; 14(6): 1-8en_US
dc.identifier.issn0975-9476
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/236897
dc.languageenen_US
dc.publisherElsevier B.V.en_US
dc.relation.issuenumber6en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.1016/j.jaim.2023.100778en_US
dc.subjectSARS-CoV-2en_US
dc.subjectViral illnessen_US
dc.subjectFlu like symptomsen_US
dc.subjectCoronavirusen_US
dc.subjectAyurvedaen_US
dc.subjectCovid-19 pandemicen_US
dc.subjectRT-PCRen_US
dc.subjectHospital stayen_US
dc.titleEffectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trialen_US
dc.typeJournal Articleen_US
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