Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trial
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Date
2023-11
Journal Title
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Publisher
Elsevier B.V.
Abstract
Background: Medicines in indigenous systems such as Ayurveda have strong antimicrobial activity but double- blind randomized control trials are infrequent in this system of medicine. The efficacy of a new ayurvedic formulation was evaluated during the pandemic. Methods: 150 mild-moderate COVID-19 patients were enrolled and randomized in 1:1 to NAOQ19 and placebo group. RT-PCR was done on Day 3, 5 and 7. CBC, CRP, LFT, and KFT were assessed at baseline and exit. Duration of hospital stay was noted and clinical assessment was also performed. Result: The results demonstrated more people turning RT-PCR negative in the NAOQ19 group compared to the placebo group on day 3 (p-value = 0.033). The mean time duration to turn RT-PCR negative was significantly lower in the NAOQ19 group (4.6 days) compared to placebo group (5.2 days) (p-value = 0.018). There was significant reduction in hospital stay among patients in the NAOQ19 arm who were discharged earlier (5.6 days) compared to placebo group (6.4 days) (p-value = 0.046). Patients in NAOQ19 arm did not show any adverse life- threatening events. Conclusion: The ayurvedic preparation given along with standard of care therapy reduced the duration of hospital stay and there was earlier conversion to RT-PCR negative.The integrated approach can help to reduce patient workload in the hospitals as well as limit the transmission of the virus in the community.
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Keywords
SARS-CoV-2, Viral illness, Flu like symptoms, Coronavirus, Ayurveda, Covid-19 pandemic, RT-PCR, Hospital stay
Citation
Bhardwaj Pankaj, Ganapathy Kalaiselvan, Pathania Monika, Naveen K.H., Charan Jaykaran, Dutta Siddhartha, Gadepalli Ravisekhar, Srinivasan Srikanth, Gupta Manoj Kumar, Goel Akhil D., Midha Naresh, Kumar Bharat, Sharma Meenakshi, Sharma Praveen, Banerjee Mithu, Mitra Prasenjit, Misra Sanjeev, V Vinayagamoorthy, Subramaniant Girija, R Praveen, Dhar Minakshi, Saxena Vartika, Dhamija Puneet, Singh Archana, Subramanian Saumya, Kanchibhotla Divya . Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trial. Journal of Ayurveda and Integrative Medicine. 2023 Nov; 14(6): 1-8