Effect of Acarbose on the Bioavailability and Pharmacokinetics of Metronidazole in Healthy and Diabetic Subjects.
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Date
2012-01
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Abstract
Although drug interactions with Acarbose are uncommon, there is a possibility for
interference with the pharmacokinetic behaviors of concomitantly administered drugs. The
present study was designed to evaluate the possible drug interactions between Acarbose
and orally administered MTZ. Twelve healthy volunteers and twelve diabetic patients were
enrolled in a randomized controlled crossover study. The effect of Acarbose (single
100mg dose) on the pharmacokinetics of MTZ was evaluated, while the effect of multiple
doses was evaluated only in diabetic patients. In both groups, 5ml blood samples were
collected into plane tubes at 0, 0.25, 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 4.0, 6.0, 8.0, 12.0, 24.0
and 48.0 hrs; serum levels of MTZ were evaluated using HPLC technique. The results
showed that diabetes mellitus significantly altered the pharmacokinetic parameters of
orally administered MTZ compared to healthy subjects. Moreover, both single and multiple
doses of Acarbose significantly changed the pharmacokinetic parameters of MTZ when
used concomitantly. The pharmacokinetics of orally administered MTZ was significantly
affected by both diabetes mellitus and concomitant use of single or multiple doses of
Acarbose.
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Keywords
Acarbose, metronidazole, type 2 DM, drug interactions
Citation
Hussain Saad A, Kurji Haydar A H, Ghareeb Mowafaq M, Abdulrazzaq Munaf H. Effect of Acarbose on the Bioavailability and Pharmacokinetics of Metronidazole in Healthy and Diabetic Subjects. British Journal of Pharmaceutical Research. 2012 Jan-Mar; 2(1): 41-49.