Pharmacological Activities of Blumea lacera (Burm. f) DC: A Medicinal Plant of Bangladesh.

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dc.contributor.authorKhair, Abul
dc.contributor.authorIbrahim, Mohammed
dc.contributor.authorAhsan, Qamrul
dc.contributor.authorHoma, Zilly
dc.contributor.authorKuddus, Md. Ruhul
dc.contributor.authorRashid, Ridwan Bin
dc.contributor.authorRashid, Mohammad Abdur
dc.date.accessioned2015-09-16T06:04:36Z
dc.date.available2015-09-16T06:04:36Z
dc.date.issued2014-07
dc.description.abstractAims: The crude methanol extract of whole plant of Blumea lacera (Burn.f.) DC. has been investigated for anti-diarrheal, antimicrobial, anxiolytic, anti-atherothrombosis, membrane stabilizing and alpha-amylase inhibitory activities. Place and Duration of Study: The study was carried out in 2013 in the Department of Pharmacy, Southern University Bangladesh, Chittagong, Bangladesh. Methodology: Test for anti-diarrheal activity was carried out by castor oil-induced diarrhea in mice. The preliminary antimicrobial activity was determined by the agar disc diffusion method. The anxiolytic activity was examined in mice by using the hole board test and open field test (OFT). The anti-atherothrombosis activity was evaluated using standard streptokinase. The membrane stabilizing activity was assessed by using hypotonic solution induced hemolysis of human erythrocyte. The plant extract was also assessed for anti-diabetic ability using In vitro α-amylase inhibitory potential. The α- amylase inhibitory activity of B. lacera was measured using the starch-iodine method. Results: The crude extract of B. lacera showed anti-diarrheal activity in dose-dependent manner. In antimicrobial assay, this extract showed better activity against the tested fungi compared to the bacteria used in the screening. Significant anxiolytic activity was found for this plant extract. In the In vitro anti-atherothrombosis test, the extract exhibited 46.17% clot lysis as compared to the standard, streptokinase (81.53%). In membrane stabilizing activity test, the plant extract at 1.0mg/ml inhibited the heat-induced hemolysis of RBCs by 52.27% whereas the standard acetyl salicylic acid (ASA) demonstrated 81.72% inhibition of hemolysis. Our results revealed that the extract had dose dependent prevention of digestion of carbohydrates by inhibiting α-amylase. The ability of B. lacera to inhibit thermal-and hypotonic-enzyme activity was found to be statistically significant (p=0.05). Conclusion: These results demonstrated that B. lacera may be used in pharmaceutical applications because of its effective pharmacological properties.en_US
dc.identifier.citationKhair Abul, Ibrahim Mohammed, Ahsan Qamrul, Homa Zilly, Kuddus Md Ruhul, Rashid Ridwan Bin, Rashid Mohammad Abdur. Pharmacological Activities of Blumea lacera (Burm. f) DC: A Medicinal Plant of Bangladesh. British Journal of Pharmaceutical Research. 2014 July; 4(13): 1677-1687.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/163505
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/5217en_US
dc.subjectBlumea laceraen_US
dc.subjectanti-diarrhealen_US
dc.subjectantimicrobialen_US
dc.subjectanxiolyticen_US
dc.subjectanti-atherothrombosisen_US
dc.subjectmembrane stabilizingen_US
dc.subjectalpha-amylaseen_US
dc.titlePharmacological Activities of Blumea lacera (Burm. f) DC: A Medicinal Plant of Bangladesh.en_US
dc.typeArticleen_US
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