Effect Of Various Concentrations Of Lignocaine & Adrenaline Combination As Local Anesthetic On Ecg Parameters Of Patients Undergoing Dental Procedures

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dc.contributor.authorB R, Sinareen_US
dc.contributor.authorGagare, Annasaheben_US
dc.contributor.authorChinmaye, Batwalen_US
dc.contributor.authorLiz, Thaliathen_US
dc.contributor.authorPatel, Prashanten_US
dc.contributor.authorRR, Kunkulolen_US
dc.contributor.authorNarwane, Sandeepen_US
dc.date.accessioned2020-05-05T07:06:35Z
dc.date.available2020-05-05T07:06:35Z
dc.date.issued2019-04
dc.description.abstractBackground:Systemic absorption of local anesthetics occurs due to its local vasodilator effects. This leads to inhibi-tory action on the heart which is represented in the form of a decrease in conduction rate, the excitability of myocardi-um and force of contraction. The aim of the present study was to evaluate the effects of Lignocaine and adrenaline combinations on electrocardiogram undergoing dental procedures. Methods:This was a prospective, observational clinical study done in collaboration with the Department of Oral & Maxillofacial Surgery. All patients scheduled for oral surgeries under local anesthesia with Lignocaine 2% and adrenaline (1:80000 or 1:200000) combination of age 18 years or above 150 patients were included in the study. Patients with a history of hepatic, renal, cardiovascular and thyroid disorders were excluded from the study. A standard 12-lead ECG (25 mm/s) was recorded for each patient before administration of drugs (Basal), during the dental procedure (Intraoperative) and immediately after completion of surgical procedure. Results:There was no statistically significant difference seen between the Group A (Lignocaine 2% with 1:80000 adrenaline) and B (Lignocaine 2% with 1:200000 adrenaline) when the age, gender, PR interval, RR interval, mean QT & QTc dispersion, and heart rate were compared. Statistically significant difference was seen in comparing the mean QT & QTc interval, which was higher in Group A. ECG parameters in Group A and B showed a statistically significant decrease in PR interval, RR interval, QT interval, QTc interval, QT dispersion and QTc disper-sion, with the basal, was compared with intraoperative and postoperative findings. The increase in heart rate although was statistically significant in both the groups, it was always within normal limits suggestive of no clinical signifi-cance. There was a statistically significant decrease in QT and QTc interval, QT and QTc dispersion. The change in all these parameters was within the physiologic range. All these relevant parameters for cardiac arrhythmias did not show any arrhythmogenic potential of lignocaine-adrenaline combination in both the groups. Both the combinations are comparable with each other in terms of ECG parameters with changes more with group A suggesting the effect of in-creased concentration of adrenaline. The change in the heart rate and ECG parameters in both the study group might be attributed to the presence of adrenaline in the combination. No cardiovascular morbidities were observed except palpitation. Conclusion:Thus it can be very well concluded that the effects of lignocaine-adrenaline combinations on electrocardiographic parameters are minimal and clinically irrelevant. Both the combination appears to be safe to use in healthy individuals.en_US
dc.identifier.affiliationsPravara Institute of Medical Sciences (Deemed University), Maharashtra.en_US
dc.identifier.affiliationsAssistant Professor, Pravara Institute of Medical Sciences (Deemed University), Maharashtraen_US
dc.identifier.affiliationsProfessor, Pravara Institute of Medical Sciences (Deemed University), Maharashtraen_US
dc.identifier.affiliationsAssociate Professor, Department of Pharmacology, Rural Medical College, Pravara Institute of Medical Sciences (Deemed University) Loni, Maharashtraen_US
dc.identifier.citationB R Sinare, Gagare Annasaheb, Chinmaye Batwal, Liz Thaliath, Patel Prashant, RR Kunkulol, Narwane Sandeep. Effect Of Various Concentrations Of Lignocaine & Adrenaline Combination As Local Anesthetic On Ecg Parameters Of Patients Undergoing Dental Procedures. International Journal of Clinical and Biomedical Research. 2019 Apr; 5(2): 32-37en_US
dc.identifier.issn2395-0471
dc.identifier.issn2521-0394
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200850
dc.languageenen_US
dc.publisherSumathi Publicationsen_US
dc.relation.issuenumber2en_US
dc.relation.volume5en_US
dc.source.urihttps://www.doi.org/10.31878/ijcbr.2019.52.07en_US
dc.subjectAdrenalineen_US
dc.subjectLignocaineen_US
dc.subjectECG parametersen_US
dc.subjectDental proceduresen_US
dc.titleEffect Of Various Concentrations Of Lignocaine & Adrenaline Combination As Local Anesthetic On Ecg Parameters Of Patients Undergoing Dental Proceduresen_US
dc.typeJournal Articleen_US
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