An Assessment Of Potential Drug-Drug Interactions In Hypertensive Patients In A Tertiary Care Hospital

Simple item page
dc.contributor.authorR., K.en_US
dc.contributor.authorM., P.en_US
dc.contributor.authorKandasamy, K.en_US
dc.contributor.authorR., S.en_US
dc.date.accessioned2020-09-24T08:00:51Z
dc.date.available2020-09-24T08:00:51Z
dc.date.issued2019-03
dc.description.abstractObjective: To an assessment of potential drug-drug interactions in hypertensive patients in a tertiary care hospital. Methods: A prospective, observational study was conducted at a tertiary care hospital, Erode for a period of 8 mo. A sample of 480 patients was assessed for PDDIs using drug checker in Micromedex®-2.7. Results: A total of 430 patients were analyzed and it was found to be 396 (82.50%) hypertensive patients had PDDIs, and a sum total of 1160 PDDIs were observed. Potential drug-drug interactions (PDDIs) higher in female hypertensive patients [255 (64.39%)] compared to males. Incidences of PDDIs were found to be higher in the age group of 60-70 y were [177 (44.69%)] and incidences of interactions based on the duration of (4-6 d) hospital stays were 272 (68.68%). Moreover, 49.24% of patients were found to be prescribed with more than 7 drugs, with higher incidences of PDDIs. Some of the most common drug interacting pair was between aspirin and clopidogrel combination observed in 325 PDDIs in the major, with pharmacodynamics in nature. Conclusion: Clinical pharmacist ought to have the role of regular monitoring of drug therapy in identifying and preventing the medications that have the potential to cause drug-drug interactions, thereby minimizing the undesirable outcomes in drug medical care and improving the quality of care.en_US
dc.identifier.affiliationsJ. K. K. Nattraja College of Pharmacy, Kumarapalayam 638183, Tamil Nadu, India,en_US
dc.identifier.affiliationsDepartmentof Pharmacy Practice,J. K. K. Nattraja College of Pharmacy, Kumarapalayam 638183, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsJ. K. K. Nattraja College of Pharmacy, Kumarapalayam 638183, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutics, J. K. K. Nattraja College of Pharmacy, Kumarapalayam 638183, Tamil Nadu, Indiaen_US
dc.identifier.citationR. K., M. P., Kandasamy K., R. S.. An Assessment Of Potential Drug-Drug Interactions In Hypertensive Patients In A Tertiary Care Hospital. International Journal of Pharmacy and Pharmaceutical Sciences. 2019 Mar; 11(3): 32-36en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/205852
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber3en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2019v11i3.30801en_US
dc.subjectHypertensive patientsen_US
dc.subjectPDDIsen_US
dc.subjectAspirin and clopidogrelen_US
dc.subjectIncidencesen_US
dc.subjectPharmacodynamicsen_US
dc.titleAn Assessment Of Potential Drug-Drug Interactions In Hypertensive Patients In A Tertiary Care Hospitalen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijpps2019v11n3p32.pdf
Size:
289.15 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Pharmacy and Pharmaceutical Sciences