Antidiabetic and antioxidant activity of Terminalia belerica. Roxb.

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dc.contributor.authorSabu, M Cen_US
dc.contributor.authorKuttan, Ramadasanen_US
dc.date.accessioned2009-05-28T16:32:08Z
dc.date.available2009-05-28T16:32:08Z
dc.date.issued2009-04-23en_US
dc.description.abstractEffect of continuous administration of dried 75% methanolic extract of fruits of Terminalia belerica (Combretaceae) suspended in water was studied in alloxan induced hyperglycemia and antioxidant defense mechanism in rats. T. belerica prevented alloxan-induced hyperglycaemia significantly from 6th day of administration and there was 54% reduction on 12th day. Oxidative stress produced by alloxan was found to be significantly lowered by the administration of T. belerica extract. This was evident from a significant decrease in thiobarbituric acid reactive substances, conjugated dienes and hydroperoxides in blood and liver respectively. Similarly, decreased glutathione level produced by alloxan was increased by the administration of the extract in blood and liver. However the increase was not significant. Superoxide dismutase which was decreased by alloxan was significantly increased from 9th day in blood and liver of drug treated group. Similarly there was significant increase in the activity of catalase in blood and liver. Decrease in glutathione peroxidase by alloxan administration was found to be increased significantly in the blood and liver from 9th day by extract treatment. Glutathione reductase also was found to be increased in blood and liver. These results suggested that T. belerica fruit extract possessed anti-diabetic and anti-oxidant activity and these activities may be interrelated.en_US
dc.description.affiliationAmala Cancer Research Centre, Amala Nagar, Thrissur, India, 680 553.en_US
dc.identifier.citationSabu MC, Kuttan R. Antidiabetic and antioxidant activity of Terminalia belerica. Roxb. Indian Journal of Experimental Biology. 2009 Apr; 47(4): 270-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63354
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/3856/1/IJEB%2047%284%29%20270-275.pdfen_US
dc.subject.meshAlloxan
dc.subject.meshAnimals
dc.subject.meshAntioxidants --pharmacology
dc.subject.meshAntioxidants --therapeutic use
dc.subject.meshBlood Glucose --drug effects
dc.subject.meshCatalase --blood
dc.subject.meshDiabetes Mellitus, Experimental --blood
dc.subject.meshDiabetes Mellitus, Experimental --drug therapy
dc.subject.meshDiabetes Mellitus, Experimental --enzymology
dc.subject.meshGlutathione Peroxidase --blood
dc.subject.meshGlutathione Reductase --blood
dc.subject.meshHypoglycemic Agents --pharmacology
dc.subject.meshHypoglycemic Agents --therapeutic use
dc.subject.meshLipid Peroxidation --drug effects
dc.subject.meshLiver --enzymology
dc.subject.meshMale
dc.subject.meshPhytotherapy
dc.subject.meshPlant Extracts --pharmacology
dc.subject.meshPlant Extracts --therapeutic use
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshSuperoxide Dismutase --blood
dc.subject.meshTerminalia --chemistry
dc.titleAntidiabetic and antioxidant activity of Terminalia belerica. Roxb.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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