Pathophysiology and genetics of obesity.

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dc.contributor.authorSrivastava, Neenaen_US
dc.contributor.authorLakhan, Ramen_US
dc.contributor.authorMittal, Balrajen_US
dc.date.accessioned2009-05-28T15:01:05Z
dc.date.available2009-05-28T15:01:05Z
dc.date.issued2007-11-13en_US
dc.description51 references.en_US
dc.description.abstractObesity, a global problem, is a multifactorial disorder. The factors are environmental, metabolic and genetic and their interaction with each other regulates the body weight. Imbalance in either of the factors may be responsible for weight gain. With advancement of research techniques in the last decade, genetic studies have been undertaken for several different causative mutations involving obesity loci on different chromosomes. Monogenic and polygenic obesity has been observed however, polygenic forms are more common. So far more than 200 genes in mouse and more than 100 genes in humans have been identified which result in phenotypes that affect body weight regulation. In spite of this knowledge, the field of obesity has still not been explored extensively. There remain a lot of lacuna regarding causes and treatment of obesity. Challenges are still there to identify the exact cause of weight gain and the use of current knowledge for development of anti-obesity drugs targeted for body weight regulation. In this review, we have explained neuropathophysiologic regulation of feeding behaviour and some aspects of obesity-genetics especially with single nucleotide polymorphism of selected candidate genes and their functional aspects mainly in monogenic obesity.en_US
dc.description.affiliationDepartment of Physiology, K G Medical University, Lucknow 226 003, India. drneenasrivstava@hotmail.comen_US
dc.identifier.citationSrivastava N, Lakhan R, Mittal B. Pathophysiology and genetics of obesity. Indian Journal of Experimental Biology. 2007 Nov; 45(11): 929-36en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61450
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/5354/1/IJEB%2045%2811%29%20929-936.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFeeding Behavioren_US
dc.subject.meshHumansen_US
dc.subject.meshObesity --epidemiologyen_US
dc.subject.meshPrevalenceen_US
dc.titlePathophysiology and genetics of obesity.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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