Comparative Effects of Garcinia kola and Garlic Extracts on Some Liver and Haematological Functions in High Salt Diet-Induced Hypertensive Wistar Rats

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dc.contributor.authorOsuji, Chigozirim A.en_US
dc.contributor.authorKalu, Achi Ngozien_US
dc.contributor.authorObioma, Ohaeri Christopheren_US
dc.contributor.authorJohn, Ohiagu Chukwuemekaen_US
dc.date.accessioned2024-09-24T06:22:59Z
dc.date.available2024-09-24T06:22:59Z
dc.date.issued2024-02
dc.description.abstractGarcinia kola is commonly consumed in Nigeria in social ceremonies, while Garlic is commonly used as a spice in the preparation of certain foods. In this study, the protective effects of extracts of the plants against a high salt diet (8% NaCl) induced hypertension were investigated in rats. Extracts prepared from the plants were subjected to phytochemical screening for acute and sub-acute toxicity studies in rats. In the protective study against salt-induced hypertension thirty-five adult male rats assigned to seven groups of five rats were treated such that, group one served as the normal control group, and group two was the hypertensive control group. Groups three to six were administered graded doses of extracts respectively after induction. While group seven received a combination of the two extracts after induction. Treatment commenced after confirmation of hypertension and lasted for two weeks before animals were sacrificed to collect blood for biochemical and haematological analysis. Results obtained showed that G.kola and Garlic feeding produced in rats following liver and haematological assays as values of these parameters in the test groups did not significantly differ from control values (p<0.05).en_US
dc.identifier.affiliationsDepartment of Biochemistry, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeriaen_US
dc.identifier.citationOsuji Chigozirim A., Kalu Achi Ngozi, Obioma Ohaeri Christopher, John Ohiagu Chukwuemeka. Comparative Effects of Garcinia kola and Garlic Extracts on Some Liver and Haematological Functions in High Salt Diet-Induced Hypertensive Wistar Rats . International Journal of Medical Research & Health Sciences. 2024-Feb; 33(2): 1-10en_US
dc.identifier.issn2231-086X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/226853
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber2en_US
dc.relation.volume33en_US
dc.source.urihttps://doi.org/10.9734/ijbcrr/2024/v33i2853en_US
dc.subjectGarcinia kola, garlic, biochemical functions, hematological parameters, albino ratsen_US
dc.titleComparative Effects of Garcinia kola and Garlic Extracts on Some Liver and Haematological Functions in High Salt Diet-Induced Hypertensive Wistar Ratsen_US
dc.typeJournal Articleen_US
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