A Pilot Study to Evaluate the Effectiveness of Carica Papaya Leaf Extract in Increasing the Platelet Count in Cases of Dengue with Thrombocytopenia.

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dc.contributor.authorGowda, A C
dc.contributor.authorKumar, N Vijay
dc.contributor.authorKasture, P N
dc.contributor.authorNagabhushan, K H
dc.date.accessioned2015-07-08T05:47:14Z
dc.date.available2015-07-08T05:47:14Z
dc.date.issued2015-03
dc.description.abstractThe pilot study was conducted to investigate the platelet increasing property of Carica papaya leaf extract (CPLE) in patients with dengue fever (DF). An open labeled randomized controlled trial was carried out at two centres of Bangalore metropolis on 30 subjects in patients with thrombocytopenia associated with dengue. The subjects were randomized into two groups, as control and intervention group. Both the groups were managed by the standard management guidelines for dengue except steroid administration. In addition to this, the intervention group received CPLE tablet three times daily for five days. All of them were followed daily with platelet monitoring. The results showed that CPLE had significant increase in the platelet count (p<0.003) over the therapy duration, in dengue fever patients, reiterating that it accelerates the increase in platelet count compared to the control group. There were few adverse events related to GI disturbance like nausea and vomiting which were similar in both groups. Thus this study concluded that Carica papaya leaf extract (CPLE) does significantly increase the platelet count in patients with thrombocytopenia associated with dengue with fewer side effects and good tolerability.en_US
dc.identifier.citationGowda A C, Kumar N Vijay, Kasture P N, Nagabhushan K H. A Pilot Study to Evaluate the Effectiveness of Carica Papaya Leaf Extract in Increasing the Platelet Count in Cases of Dengue with Thrombocytopenia. Indian Medical Gazette. 2015 Mar; 149 (3): 109-116.en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/159275
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/ice/t15/i3/icet15i3p109.pdfen_US
dc.subjectcarica papaya leaf extracten_US
dc.subjectthrombocytopeniaen_US
dc.subjectincreased plateletsen_US
dc.subjectdengueen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshBlood Platelets --physiology
dc.subject.meshBlood Platelets --virology
dc.subject.meshCarica --therapeutic use
dc.subject.meshDengue --complications
dc.subject.meshDengue --drug therapy
dc.subject.meshDengue --epidemiology
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshMale
dc.subject.meshPlant Extracts
dc.subject.meshPlant Leaves
dc.subject.meshThrombocytopenia --drug therapy
dc.subject.meshThrombocytopenia --epidemiology
dc.subject.meshThrombocytopenia --etiology
dc.subject.meshYoung Adult
dc.titleA Pilot Study to Evaluate the Effectiveness of Carica Papaya Leaf Extract in Increasing the Platelet Count in Cases of Dengue with Thrombocytopenia.en_US
dc.typeArticleen_US
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