A Pilot Study to Evaluate the Effectiveness of Carica Papaya Leaf Extract in Increasing the Platelet Count in Cases of Dengue with Thrombocytopenia.
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Date
2015-03
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Abstract
The pilot study was conducted to investigate the platelet
increasing property of Carica papaya leaf extract (CPLE)
in patients with dengue fever (DF). An open labeled
randomized controlled trial was carried out at two centres
of Bangalore metropolis on 30 subjects in patients with
thrombocytopenia associated with dengue.
The subjects were randomized into two groups, as
control and intervention group. Both the groups were
managed by the standard management guidelines for dengue
except steroid administration. In addition to this, the
intervention group received CPLE tablet three times daily
for five days. All of them were followed daily with platelet
monitoring. The results showed that CPLE had significant
increase in the platelet count (p<0.003) over the therapy
duration, in dengue fever patients, reiterating that it
accelerates the increase in platelet count compared to the
control group. There were few adverse events related to
GI disturbance like nausea and vomiting which were similar
in both groups. Thus this study concluded that Carica
papaya leaf extract (CPLE) does significantly increase the
platelet count in patients with thrombocytopenia associated with dengue with fewer side effects and good tolerability.
Description
Keywords
carica papaya leaf extract, thrombocytopenia, increased platelets, dengue
Citation
Gowda A C, Kumar N Vijay, Kasture P N, Nagabhushan K H. A Pilot Study to Evaluate the Effectiveness of Carica Papaya Leaf Extract in Increasing the Platelet Count in Cases of Dengue with Thrombocytopenia. Indian Medical Gazette. 2015 Mar; 149 (3): 109-116.