Evolution of Rodent Pheromones: A Review of the ABPs with Comparison to the ESPs and the MUPs.
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Date
2013-10
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Abstract
Three proteinaceous pheromone families, the androgen-binding proteins (ABPs), the
exocrine-gland secreting peptides (ESPs) and the major urinary proteins (MUPs) are
encoded by large gene families in the Mus musculus and Rattus norvegicus genomes. The
purpose of this article is to review what is known about the evolutionary histories of the the
Abp gene family expansions in rodents and, where appropriate, to compare them to what
is known of the expansions of the Mup and Esp gene families. The issues important to
these histories are the extent of the gene family expansions, the timing of their expansions
and the roles played by selection, gene conversion and non-allelic homologous
recombination (NAHR). I also compare and contrast the evolutionary histories of all three
mouse gene families in light of the proposed functions of their pheromones in mouse
communication.
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Keywords
Rodent, androgen-binding protein, exocrine gland secreting peptides, major urinary proteins, evolutionary history, gene duplication, gene family expansion
Citation
Karn Robert C. Evolution of Rodent Pheromones: A Review of the ABPs with Comparison to the ESPs and the MUPs. International Journal of Biochemistry Research & Review 2013 Oct-Dec ; 3 (4) : 328-363.