Assessment of larvicidal, growth-suppressing, and development-altering bioefficacy of Ageratum houstonianum against Aedes aegypti (L.)

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dc.contributor.authorShah, Vijay Kumaren_US
dc.contributor.authorGupta, Kamal Kumaren_US
dc.date.accessioned2025-08-13T09:35:52Z
dc.date.available2025-08-13T09:35:52Z
dc.date.issued2025-03
dc.description.abstractBackground & objectives: Aedes aegypti is a major vector responsible for spreading dengue, chikungunya, yellow fever, and Zika viruses worldwide. These illnesses have increased globally due to climate and environmental changes. Vector control and management are the principal tactics for combating mosquitoes-borne diseases in the absence of an effective vaccine. The study aimed to ascertain bioactivities of Ageratum houstonianum leaf acetone extract (AhLAE) against Ae. aegypti. Methods: Bioefficacy of AhLAE was tested against fourth instar larvae (L4) of Ae. aegypti using standard WHO protocol. The mortality, growth, and development of larvae, pupae and adults were recorded after exposure to the extract. Results: The AhLAE showed larvicidal activity against L4 with LC50 and LC90 values of 401.88 and 691.24 mg/L, respectively. The mortality of the larvae further increased on subsequent days. The AhLAE caused a significant reduction in pupae formation and adult emergence. It also increased the larval duration of L4 and development duration of the pupa formed from the treated L4, indicating its growth-suppressing effects. The impact of the AhLAE was dose-dependent; high concentrations caused reduction in survival and growth of L4. Consequently, the L4-pupal and L4-adult growth indexes decreased. Additionally, the AhLAE induced developmental anomalies in the form of larva-pupa (L-P) intermediates. Interpretation & conclusion: The study found that the AhLAE exhibited larvicidal, growth-suppressing, and development-altering activities against Ae. aegypti. The findings suggest the potential of AhALE as a natural insecticidal agent for controlling mosquitoes.en_US
dc.identifier.affiliationsInsect Reproduction Laboratory, Department of Zoology, Deshbandhu College, University of Delhi, Kalkaji, Delhi, Indiaen_US
dc.identifier.affiliationsInsect Reproduction Laboratory, Department of Zoology, Deshbandhu College, University of Delhi, Kalkaji, Delhi, Indiaen_US
dc.identifier.citationShah Vijay Kumar, Gupta Kamal Kumar. Assessment of larvicidal, growth-suppressing, and development-altering bioefficacy of Ageratum houstonianum against Aedes aegypti (L.). Journal of Vector Borne Diseases . 2025 Mar; 62(1): 67-77en_US
dc.identifier.issn0972-9062
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252568
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume62en_US
dc.source.urihttps://doi.org/10.4103/JVBD.JVBD_100_24https://creativecommons.org/licenses/by-nc-sa/4.0en_US
dc.subjectAedes aegyptien_US
dc.subjectAgeratum houstonianumen_US
dc.subjectlarvicidal activityen_US
dc.subjectlarva-pupa (L-P) intermediatesen_US
dc.subjectgrowth & developmenten_US
dc.titleAssessment of larvicidal, growth-suppressing, and development-altering bioefficacy of Ageratum houstonianum against Aedes aegypti (L.)en_US
dc.typeJournal Articleen_US
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