Serotonin/dopamine interaction--focus on 5-HT2C receptor, a new target of psychotropic drugs.

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dc.contributor.authorDi Giovanni, Gen_US
dc.contributor.authorDi Matteo, Ven_US
dc.contributor.authorEsposito, Een_US
dc.date.accessioned2009-05-28T12:48:07Z
dc.date.available2009-05-28T12:48:07Z
dc.date.issued2002-12-17en_US
dc.description48 references.en_US
dc.description.abstractSeveral hypotheses regarding physiopathology of major psychiatric diseases exist. Attention has been focused on cerebral monoaminergic systems, the dysfunction of which is thought to underlie various aspects of their symptomatology. There are reports describing the involvement of serotonergic and dopaminergic systems in the mechanism of action of psychotropic drugs. This article reviews current knowledge on interaction between 5-hydroxytryptamine (5-HT), acting at 5-HT2C receptors in the central dopamine (DA) systems. Since 90s, a growing body of behavioural, neurochemical and electrophysiological evidence from animal studies have demonstrated a clear role for 5-HT2C receptors in modulation of activity of dopamine neurones. This evidence has led to the suggestion that drugs acting on 5-HT2C receptors have potential as novel antipsychotic and antidepressant agents and may also be used in the treatment of other neuropsychiatric disorders such as Parkinson's disease and psychoactive substance abuse.en_US
dc.description.affiliationDipartimento di Medicina Sperimentale, Sezione di Fisiologia Umana G. Pagano, Università di Palermo, C.so Tuköry, 129 1-90134 Palermo, Italy. giudigiova@hotmail.comen_US
dc.identifier.citationDi Giovanni G, Di Matteo V, Esposito E. Serotonin/dopamine interaction--focus on 5-HT2C receptor, a new target of psychotropic drugs. Indian Journal of Experimental Biology. 2002 Dec; 40(12): 1344-52en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58571
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshPsychotropic Drugs --pharmacologyen_US
dc.subject.meshReceptor, Serotonin, 5-HT2Cen_US
dc.subject.meshReceptors, Serotonin --drug effectsen_US
dc.titleSerotonin/dopamine interaction--focus on 5-HT2C receptor, a new target of psychotropic drugs.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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