Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer

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dc.contributor.authorWu, Xiangmeien_US
dc.contributor.authorDuan, Lijiangen_US
dc.date.accessioned2025-08-13T11:40:49Z
dc.date.available2025-08-13T11:40:49Z
dc.date.issued2025-06
dc.description.abstractBackground: Investigation of a potential prognostic marker expressed innon?small cell lung cancer (NSCLC) can help patients benefit from newtarget therapeuticmodalities. Aims: To study the expression and correlationof P53 protein and epithelial–mesenchymal transition (EMT) relatedmakers in NSCLC. Materials and Methods: 32 cases were selected forimmunohistochemistry analysis to evaluate the expression of P53 andEMT?related makers. Results: The positive expression rate of P53 and theincidence of EMT in NSCLC were closely linked to TNM stages, differentiationdegree, and lymph node metastasis (P < 0.05). A positive association was foundbetween P53 and EMT (r = 0.380, P < 0.05). Conclusions: There is a positiveassociation between P53, snail, and EMT. P53 may affect EMT in NSCLC byup?regulating the expression of Snail and further promoting cancer invasionand metastasis.en_US
dc.identifier.affiliationsDepartment of Pathology, Beijing Geriatric Hospital, Beijing, Chinaen_US
dc.identifier.affiliationsDepartment of Pathology, Beijing Geriatric Hospital, Beijing, Chinaen_US
dc.identifier.citationWu Xiangmei, Duan Lijiang . Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer. Indian Journal of Pathology & Microbiology. 2025 Jun; 68(2): 300-304en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/253969
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber2en_US
dc.relation.volume68en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_277_24en_US
dc.subjectEpithelial–mesenchymal transitionen_US
dc.subjectimmunohistochemistryen_US
dc.subjectnon?small cell lung canceren_US
dc.subjectP53en_US
dc.titleCorrelation of P53 expression and epithelial-mesenchymal transition in non-small cell lung canceren_US
dc.typeJournal Articleen_US
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