Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer
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Date
2025-06
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Wolters Kluwer - Medknow
Abstract
Background: Investigation of a potential prognostic marker expressed innon?small cell lung cancer (NSCLC) can help patients benefit from newtarget therapeuticmodalities. Aims: To study the expression and correlationof P53 protein and epithelial–mesenchymal transition (EMT) relatedmakers in NSCLC. Materials and Methods: 32 cases were selected forimmunohistochemistry analysis to evaluate the expression of P53 andEMT?related makers. Results: The positive expression rate of P53 and theincidence of EMT in NSCLC were closely linked to TNM stages, differentiationdegree, and lymph node metastasis (P < 0.05). A positive association was foundbetween P53 and EMT (r = 0.380, P < 0.05). Conclusions: There is a positiveassociation between P53, snail, and EMT. P53 may affect EMT in NSCLC byup?regulating the expression of Snail and further promoting cancer invasionand metastasis.
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Keywords
Epithelial–mesenchymal transition, immunohistochemistry, non?small cell lung cancer, P53
Citation
Wu Xiangmei, Duan Lijiang . Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer. Indian Journal of Pathology & Microbiology. 2025 Jun; 68(2): 300-304