Role of chelating agents and antioxidants in beryllium induced toxicity.

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dc.contributor.authorJohri, Soniaen_US
dc.contributor.authorShukla, Sangeetaen_US
dc.contributor.authorSharma, Pragyaen_US
dc.date.accessioned2009-05-28T15:15:55Z
dc.date.available2009-05-28T15:15:55Z
dc.date.issued2002-05-08en_US
dc.description.abstractThe present study was conducted to evaluate the therapeutic effectiveness of chelating agents [glutathione, 2,3 dimercapto propane sulfonic acid (DMPS) and D-penicillamine (DPA)] in combination with antioxidant (sodium selenite) in beryllium induced toxicity in female rats. A bolus dose of 50mg/kg-beryllium nitrate was administered singly followed by chelation therapy with GSH, DMPS + Se and DPA + Se at various durations of 1,3 and 7 days respectively. Results revealed a significant fall in the glycogen content, whereas, a marginal fall in the protein was also observed. The enzymatic activity of alkaline phosphatase and adenosine triphosphatase was depleted; on the contrary, there was a significant rise in the acid phosphatase and glucose-6-phosphatase pattern. A rise in the hepatic lipid peroxidation activity is a direct indication of oxidative damage resulting in free radical generation. The distribution of the metal by atomic absorption spectrophotometry revealed an increased concentration of beryllium in liver and kidney, followed by lung and uterus. The relative ability of three chelating agents to act as antagonists, for acute beryllium poisoning, have been examined in liver, kidney, lungs and uterus. The appreciable change in the beryllium concentration in various organs is duration dependent during the entire period being highly significant at 7 days regimen. Biochemical and distribution studies reveal that DPA + Se was the most effective therapeutic agent followed by DMPS + Se and GSH.en_US
dc.description.affiliationLaboratory of Toxicology & Reproductive Biology, School of Studies in Zoology, Jiwaji University, Gwalior, 474 011, India.en_US
dc.identifier.citationJohri S, Shukla S, Sharma P. Role of chelating agents and antioxidants in beryllium induced toxicity. Indian Journal of Experimental Biology. 2002 May; 40(5): 575-82en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61765
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants --pharmacologyen_US
dc.subject.meshBeryllium --toxicityen_US
dc.subject.meshChelating Agents --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshRatsen_US
dc.titleRole of chelating agents and antioxidants in beryllium induced toxicity.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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