Factors influencing in-hospital length of stay and mortality in cancer patients suffering from febrile neutropenia.

Simple item page
dc.contributor.authorLal, Amaren_US
dc.contributor.authorBhurgri, Yasminen_US
dc.contributor.authorRizvi, Nidaen_US
dc.contributor.authorVirwani, Mohnien_US
dc.contributor.authorMemon, Rasheed Uddinen_US
dc.contributor.authorSaeed, Wajeehaen_US
dc.contributor.authorSardar, Muhammad Rizwanen_US
dc.contributor.authorKumar, Pawanen_US
dc.contributor.authorShaikh, Asim Jamalen_US
dc.contributor.authorAdil, Salmanen_US
dc.contributor.authorMasood, Nehalen_US
dc.contributor.authorKhurshed, Mohammeden_US
dc.date.accessioned2009-05-27T17:42:48Z
dc.date.available2009-05-27T17:42:48Z
dc.date.issued2008-04-21en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractINTRODUCTION: Febrile neutropenia (FN) is a major complication of chemotherapy, costly in terms of morbidity, mortality and associated financial expenditure. The present study was conducted with the goal of highlighting FN as a serious problem in Pakistan, with the longer term objective of improved cancer survival, reduction in length of stay (LOS) in hospital, morbidity, mortality and costs in our existing developing country scenario. METHODS: A cross-sectional descriptive study was conducted on patients, > or =18 years, admitted with FN as a consequence of chemotherapy at a referral hospital in Karachi from 1st September 2006 to 30th April 2007. RESULTS: A total of 80 patients [43 (53.8%) males and 37 (46.2%) females] were selected. The mean age was 47.4 (SD +/-16.6; range 18-79) years. Sixty eight patients (86%) were < or = 65 years, 50% were < or = 50 years. Overall, inhospital mortality was 11%; 4% for patients on granulocyte colony stimulating factor (G-CSF) prophylaxis as against 20% for those without. The cause of death was either pneumonia or septic shock. Mean LOS was 7.53 (SD +/-3.8; range 2-17) days. Hematological malignancies, older age, severity of dehydration, pneumonia and culture positivity were significantly associated with LOS and death. Those above 50 years of age were 1.5 times as likely to be hospitalized longer and > three times as likely to die. Bacteremia conferred a 5-fold and pneumonia an 8-fold increase in the risk of death. CONCLUSION: The results of this study indicate that age, vital instability, dehydration, high creatinine, culture positivity and hematological malignancies are high risk factors in chemotherapy induced FN. Identification of FN risk factors with poor outcomes may help in devising protocols for modified dosage or including GCFs initially. This may help reduce the cost of cancer care as well as mortality and morbidity. Prospective studies of FN in multiple centers in Pakistan may be beneficial in evaluating these risk factors further.en_US
dc.description.affiliationSection of Medical Oncology and Hematology, Department of Medicine, Aga Khan University Hospital, Karachi.en_US
dc.identifier.citationLal A, Bhurgri Y, Rizvi N, Virwani M, Memon RU, Saeed W, Sardar MR, Kumar P, Shaikh AJ, Adil S, Masood N, Khurshed M. Factors influencing in-hospital length of stay and mortality in cancer patients suffering from febrile neutropenia. Asian Pacific Journal of Cancer Prevention. 2008 Apr-Jun; 9(2): 303-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37732
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFever --chemically induceden_US
dc.subject.meshHealth Care Costsen_US
dc.subject.meshHospital Mortality --trendsen_US
dc.subject.meshHospitalization --statistics & numerical dataen_US
dc.subject.meshHumansen_US
dc.subject.meshLength of Stayen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasms --drug therapyen_US
dc.subject.meshNeutropenia --chemically induceden_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshYoung Adulten_US
dc.titleFactors influencing in-hospital length of stay and mortality in cancer patients suffering from febrile neutropenia.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Asian Pacific Journal of Cancer Prevention