Correlation between pulmonary function tests and inflammatory markers in familial mediterranean fever patients
Loading...
Date
2019-02
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
Background: Familial mediterranean fever (FMF) is a disease frequently seen in some races and characterized by recurrent attacks affecting various organs with chronic inflammation. As a result of chronic inflammation, microvascular changes may occur. In this study, we aimed to investigate the association between pulmonary function tests and inflammatory markers in FMF patients.Methods: Seventy-five FMF patients followed up at the Department of Internal Medicine who did not have any comorbidity affecting lung functions and 64 healthy subjects were enrolled. Both groups underwent CO (carbon monoxide) diffusion analysis and pulmonary function tests. Inflammatory markers of the groups were recorded as well and compared with CO diffusion and pulmonary function tests.Results: FVC%, FEV1, FEV1%, FEV1/FVC, PEF, FEF25-75% values of the patient group was significantly lower than those in the control group. When compared, DLCO%, DLCO/VA, DLCO/VA% were also significantly lower than controls. There was a significant correlation between pulmonary function tests and ESR, hsCRP and fibrinogen levels.Conclusions: Inflammation in FMF patients may lead to damage on pulmonary tissue that causes an impairment in pulmonary functions.
Description
Keywords
Familial mediterranean fever, Pulmonary function tests, Carbon monoxide diffusion analyses
Citation
Saler Tayyibe, Co?kun Murat, Süleyman Ahbab, Benan Ça?layan, Zuhal Aydan Sa?lam, Betül Çavu?o?lu Türker, Fatih Türker, Mehmet Bankir, Nurettin Ay, ?akir Özgür Ke?kek . Correlation between pulmonary function tests and inflammatory markers in familial mediterranean fever patients. International Journal of Community Medicine and Public Health. 2019 Feb; 6(2): 468-472