Remote ischaemic preconditioning and prevention of cerebral injury.

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dc.contributor.authorRehni, Ashish Ken_US
dc.contributor.authorShri, Richaen_US
dc.contributor.authorSingh, Manjeeten_US
dc.date.accessioned2009-05-28T13:15:50Z
dc.date.available2009-05-28T13:15:50Z
dc.date.issued2007-03-22en_US
dc.description.abstractBilateral carotid artery occlusion of 10 min followed by reperfusion for 24 hr was employed in present study to produce ischaemia and reperfusion induced cerebral injury in mice. Cerebral infarct size was measured using triphenyltetrazolium chloride staining. Short-term memory was evaluated using elevated plus maze. Inclined beam walking test was employed to assess motor incoordination. Bilateral carotid artery occlusion followed by reperfusion produced cerebral infarction and impaired short-term memory, motor co-ordination and lateral push response. A preceding episode of mesenteric artery occlusion for 15 min and reperfusion of 15 min (remote mesenteric ischaemic preconditioning) prevented markedly ischaemia-reperfusion-induced cerebral injury measured in terms of infarct size, loss of short-term memory, motor coordination and lateral push response. Glibenclamide (5 mg/kg, iv) a KATP channel blocker and caffeine (7 mg/kg, iv) an adenosine receptor blocker attenuated the neuroprotective effect of remote mesenteric ischaemic preconditioning. It may be concluded that neuroprotective effect of remote mesenteric ischaemic preconditioning may be due to activation of adenosine receptors and consequent activation of KATP channels in mice.en_US
dc.description.affiliationDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147 002, India. ashishkrehni@yahoo.co.inen_US
dc.identifier.citationRehni AK, Shri R, Singh M. Remote ischaemic preconditioning and prevention of cerebral injury. Indian Journal of Experimental Biology. 2007 Mar; 45(3): 247-52en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59179
dc.language.isoengen_US
dc.relation.urihttps://nopr.niscair.res.in/bitstream/123456789/5242/1/IJEB%2045%283%29%20247-252.pdfen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain Injuries --prevention & controlen_US
dc.subject.meshIschemic Preconditioningen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred BALB Cen_US
dc.titleRemote ischaemic preconditioning and prevention of cerebral injury.en_US
dc.typeJournal Articleen_US
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