Biochemical studies on hypoglycemic effect of Aavirai kudineer: a herbal formulation in alloxan diabetic rats.

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dc.contributor.authorBhavapriya, Ven_US
dc.contributor.authorKalpana, Sen_US
dc.contributor.authorGovindasamy, Sen_US
dc.contributor.authorApparanantham, Ten_US
dc.date.accessioned2009-05-28T15:50:48Z
dc.date.available2009-05-28T15:50:48Z
dc.date.issued2001-09-08en_US
dc.description.abstractAavirai Kudineer (AK) is an herbal decoction of seven botanical drugs, cited in the Gunapadam; a Tamil Siddha medical text. The anti-diabetic efficacy of this formulation was evaluated using alloxan-induced diabetic and normal rats. Glucose tolerance was observed within 1 hr in AK-treated rats (10 ml/kg body ) as compared to control. A significant decrease in the severe hyperglycemia characteristic of alloxan diabetes was noted after 15 days of AK treatment. Further AK treatment reversed the elevated urea, creatinine, cholesterol and decreased protein values to near normal levels. Assay of glycogen content and chief carbohydrate-metabolizing enzymes, viz. hexokinase, glucose-6-phosphatase and fructose 1,6 diphosphatase in the liver of diabetic and AK-treated diabetic rats clearly ascertains the hypoglycemic efficacy of this formulation. The mode of action of this herbal formulation remains to be elucidated.en_US
dc.description.affiliationDepartment of Biochemistry and Molecular Biology, University of Madras, Chennai, India.en_US
dc.identifier.citationBhavapriya V, Kalpana S, Govindasamy S, Apparanantham T. Biochemical studies on hypoglycemic effect of Aavirai kudineer: a herbal formulation in alloxan diabetic rats. Indian Journal of Experimental Biology. 2001 Sep; 39(9): 925-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/62488
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Glucose --metabolismen_US
dc.subject.meshCholesterol --blooden_US
dc.subject.meshCreatinine --blooden_US
dc.subject.meshDiabetes Mellitus, Experimental --blooden_US
dc.subject.meshFructose-Bisphosphatase --metabolismen_US
dc.subject.meshGlucose-6-Phosphatase --metabolismen_US
dc.subject.meshGlycogen --metabolismen_US
dc.subject.meshHexokinase --metabolismen_US
dc.subject.meshHypoglycemic Agents --therapeutic useen_US
dc.subject.meshMaleen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Preparations --therapeutic useen_US
dc.subject.meshPlants, Medicinalen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshUrea --blooden_US
dc.titleBiochemical studies on hypoglycemic effect of Aavirai kudineer: a herbal formulation in alloxan diabetic rats.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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