Butachlor is cytotoxic and clastogenic and induces apoptosis in mammalian cells.

dc.contributor.authorPanneerselvam, Nen_US
dc.contributor.authorSinha, Sen_US
dc.contributor.authorShanmugam, Gen_US
dc.date.accessioned2009-05-28T10:40:18Z
dc.date.available2009-05-28T10:40:18Z
dc.date.issued1999-09-25en_US
dc.description.abstractThe ability of butachlor to induce cytotoxicity, clastogenicity and DNA damage was assessed using Chinese hamster ovary cells (CHO), Swiss mouse embryo fibroblasts (MEF) and human peripheral blood lymphocytes. A dose and time dependent loss of viability was evident upon treatment of CHO cells with butachlor. Cell killing to an extent of 50% was observed when cells were treated with 16.2 micrograms/ml of butachlor for 24 hr or with 11.5 micrograms/ml for 48 hr. The herbicide induced micronuclei significantly in cultured lymphocytes at 24 and 48 hr of treatment suggesting that it is clastogenic. To understand the mechanism of cell death caused by butachlor, its effect on DNA strand breaks was studied in MEF. A concomitant decrease in cell viability was observed with increase in DNA strand breaks. Agarose gel electrophoresis of DNA from herbicide treated CHO cells and cytochemical staining indicate the induction of apoptosis by butachlor.en_US
dc.description.affiliationCancer Biology Division, School of Biological Sciences, Madurai Kamaraj University, India.en_US
dc.identifier.citationPanneerselvam N, Sinha S, Shanmugam G. Butachlor is cytotoxic and clastogenic and induces apoptosis in mammalian cells. Indian Journal of Experimental Biology. 1999 Sep; 37(9): 888-92en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/55632
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAcetanilides --toxicityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCHO Cellsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshCricetinaeen_US
dc.subject.meshEmbryo, Mammalian --cytologyen_US
dc.subject.meshFibroblasts --drug effectsen_US
dc.subject.meshHerbicides --toxicityen_US
dc.subject.meshHumansen_US
dc.subject.meshMiceen_US
dc.subject.meshMutagens --toxicityen_US
dc.titleButachlor is cytotoxic and clastogenic and induces apoptosis in mammalian cells.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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