DPP-4 inhibitory activity and myocardial salvaging effects of Commiphora mukul in experimental diabetes

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dc.contributor.authorBorde, Manjusha K.en_US
dc.contributor.authorMohanty, Ipseeta Rayen_US
dc.contributor.authorMaheshwari, Ujwalaen_US
dc.contributor.authorSuman, Rajesh Kumaren_US
dc.contributor.authorDeshmukh, Y. A.en_US
dc.date.accessioned2020-04-23T07:54:51Z
dc.date.available2020-04-23T07:54:51Z
dc.date.issued2019-03
dc.description.abstractBackground: Commiphora mukul (Burseraceae) is commonly known as Guggul in Ayurveda. Several studies have reported antidiabetic activity of Commiphora mukul but there are no studies to explore the DPP-4 inhibitory activity and myocardial salvaging effects of Commiphora mukul in setting of diabetes mellitus. The present study was designed to evaluate the cardioprotective efficacy as well as safety of the medicinal plant Commiphora mukul (Guggul) in the experimental model of myocardial infarction co-existing with diabetes.Methods: Diabetes was induced with single dose of streptozotocin (STZ): 45mg/kg ip and myocardial infarction was produced by administering isoproterenol (ISP): (85mg/kg, sc) to rats 24 and 48 h prior to scarification (5th week). After the confirmation of diabetes on 7th day (glucose>200mg/dl), vildagliptin (10 mg/kg) and Commiphora mukul (200 mg/kg) were administered orally from 1st to 5th week (4 weeks). At the end of experimental period, normal control, diabetic-isoproterenol control, vildagliptin and Commiphora mukul group rats were sacrificed for further biochemical investigations as well as histopathological evaluation.Results: Commiphora mukul treatment demonstrated significant antidiabetic as well as myocardial salvaging effects as indicated by restoration of blood glucose, HbA1c and CPK-MB serum DPP-4, hs-CRP levels as compared to diabetic ISP control group. In addition, Commiphora mukul showed significant cardioprotection as indicated by positive correlation between cardiac marker CPK-MB and serum DPP-4. The histopathological assessment of heart, pancreas and biochemical indices of injury confirmed the cardioprotective effects of Commiphora mukul. In addition, Commiphora mukul was found to be safe to the liver and kidney.Conclusions: The natural DPP-4 inhibitor Commiphora mukul demonstrated significant cardioprotective effects in experimental model of myocardial infarction co-existing with diabetes.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Sinhgad Dental College and Hospital, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, MGM Medical College, Navi Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, MGM Medical College, Navi Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Hind Institute of Medical Sciences, Ataria, Sitapur, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.citationBorde Manjusha K., Mohanty Ipseeta Ray, Maheshwari Ujwala, Suman Rajesh Kumar, Deshmukh Y. A.. DPP-4 inhibitory activity and myocardial salvaging effects of Commiphora mukul in experimental diabetes. International Journal of Basic & Clinical Pharmacology. 2019 Mar; 8(3): 575-583en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200067
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20190668en_US
dc.subjectCommiphora mukulen_US
dc.subjectDPP-4 inhibitoren_US
dc.subjectDiabetesen_US
dc.subjectExperimental modelen_US
dc.subjectMyocardial infarctionen_US
dc.titleDPP-4 inhibitory activity and myocardial salvaging effects of Commiphora mukul in experimental diabetesen_US
dc.typeJournal Articleen_US
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