Stability Indicating Method for the Determination of Mefenamic Acid in Pharmaceutical Formulations by HPLC.

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dc.contributor.authorDhumal, Bhagyashree R
dc.contributor.authorBhusari, Kishore P
dc.contributor.authorTajne, Madhukar R
dc.contributor.authorGhante, Mahavir H
dc.contributor.authorJain, Nishant S
dc.date.accessioned2015-07-04T08:57:53Z
dc.date.available2015-07-04T08:57:53Z
dc.date.issued2014-12
dc.description.abstractA simple, RP-HPLC stability indicating method was developed for determination of mefenamic acid in pharmaceutical formulations and its degradation products using C8 column with the mobile phase containing mixture of Buffer : Acetonitrile + THF in the ratio of 55:45 v/v at a flow rate of 1.0 ml/min was found to yield satisfactory retention time of about 18.253 min with sharp symmetrical peak at a detection wavelength of 285 nm. The method was validated using ICH guidelines and was found to be linear in the range 0.5-2 μg/ mL. The proposed method shows good separation of mefenamic acid and its degradation products. The developed method can be applied successfully for the determination of mefenamic acid and its degraded products.en_US
dc.identifier.citationDhumal Bhagyashree R, Bhusari Kishore P, Tajne Madhukar R, Ghante Mahavir H, Jain Nishant S. Stability Indicating Method for the Determination of Mefenamic Acid in Pharmaceutical Formulations by HPLC. Journal of Applied Pharmaceutical Science. 2014 Dec; 4(12): 60-64.en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/159040
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/counter.php?aid=1392en_US
dc.subjectHPLCen_US
dc.subjectMefenamic aciden_US
dc.subjectStress degradationen_US
dc.titleStability Indicating Method for the Determination of Mefenamic Acid in Pharmaceutical Formulations by HPLC.en_US
dc.typeArticleen_US
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