Stability Indicating Method for the Determination of Mefenamic Acid in Pharmaceutical Formulations by HPLC.
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Date
2014-12
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Abstract
A simple, RP-HPLC stability indicating method was developed for determination of mefenamic acid in
pharmaceutical formulations and its degradation products using C8 column with the mobile phase containing
mixture of Buffer : Acetonitrile + THF in the ratio of 55:45 v/v at a flow rate of 1.0 ml/min was found to yield
satisfactory retention time of about 18.253 min with sharp symmetrical peak at a detection wavelength of 285
nm. The method was validated using ICH guidelines and was found to be linear in the range 0.5-2 μg/ mL. The
proposed method shows good separation of mefenamic acid and its degradation products. The developed method
can be applied successfully for the determination of mefenamic acid and its degraded products.
Description
Keywords
HPLC, Mefenamic acid, Stress degradation
Citation
Dhumal Bhagyashree R, Bhusari Kishore P, Tajne Madhukar R, Ghante Mahavir H, Jain Nishant S. Stability Indicating Method for the Determination of Mefenamic Acid in Pharmaceutical Formulations by HPLC. Journal of Applied Pharmaceutical Science. 2014 Dec; 4(12): 60-64.