Antidiarrhoeal evaluation of rhizomes of Cryptocoryne spiralis Fisch. ex Wydler: Antimotility and antisecretory effects.

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dc.contributor.authorPrasad, Satyendra K
dc.contributor.authorLaloo, Damiki
dc.contributor.authorKumar, Rajesh
dc.contributor.authorSahu, Alakh N
dc.contributor.authorHemalatha, S
dc.date.accessioned2014-04-29T11:12:38Z
dc.date.available2014-04-29T11:12:38Z
dc.date.issued2014-02
dc.description.abstractThe antidiarrhoeal activity of Cryptocoryne spiralis rhizomes extract (250, 500, 750 mg/kg, po) was evaluated using faecal excretion, castor oil-induced diarrhoea, small intestinal transit, intestinal fluid accumulation, gastric emptying and PGE2 induced enteropooling models in rats. In addition, various biochemical estimations, histopathological studies and antibacterial evaluations on strains responsible for diarrhoea were also performed. The results illustrated a significant reduction in normal faecal output rate after 5th and 7th h of treatment, while castor oil-induced diarrhoea model depicted a protection of 55.44% at same dose level from diarrhoea. The other models except, gastric emptying test demonstrated more pronounced effect at same dose level. A significant inhibition in nitric oxide, increase in carbohydrates, protein, DNA, Na+ and K+ level with minimum degeneration of colonic fibrous tissues and potent antibacterial activity were also observed. The antidiarrhoeal potential of C. spiralis may be as a result of antimotility and antisecretory type effect mediated through nitric oxide pathway.en_US
dc.identifier.citationPrasad Satyendra K, Laloo Damiki, Kumar Rajesh, Sahu Alakh N, Hemalatha S. Antidiarrhoeal evaluation of rhizomes of Cryptocoryne spiralis Fisch. ex Wydler: Antimotility and antisecretory effects. Indian Journal of Experimental Biology. 2014 Feb; 52(2): 139-146.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/150342
dc.language.isoenen_US
dc.rightshttps://nopr.niscair.res.in/handle/123456789/26440en_US
dc.subjectAconitum heterophyllumen_US
dc.subjectAntidiarrhoeal activityen_US
dc.subjectCastor oil induced diarrhoeaen_US
dc.subjectCryptocoryne spiralisen_US
dc.subjectPGE2 induced enteropoolingen_US
dc.subjectSmall intestinal transiten_US
dc.subject.meshAnimals
dc.subject.meshAntidiarrheals --administration & dosage
dc.subject.meshAntidiarrheals --chemistry
dc.subject.meshAraceae --chemistry
dc.subject.meshCastor Oil --toxicity
dc.subject.meshDiarrhea --chemically induced
dc.subject.meshDiarrhea --drug therapy
dc.subject.meshDiarrhea --pathology
dc.subject.meshHumans
dc.subject.meshMetabolic Networks and Pathways --drug effects
dc.subject.meshNitric Oxide --metabolism
dc.subject.meshPlant Extracts --administration & dosage
dc.subject.meshPlant Extracts --chemistry
dc.subject.meshRats
dc.subject.meshRhizome --chemistry
dc.titleAntidiarrhoeal evaluation of rhizomes of Cryptocoryne spiralis Fisch. ex Wydler: Antimotility and antisecretory effects.en_US
dc.typeArticleen_US
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