Effect of aspirin and sodium salicylate on cataract development in diabetic rats.

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dc.contributor.authorShastri, G Ven_US
dc.contributor.authorThomas, Men_US
dc.contributor.authorVictoria, A Jen_US
dc.contributor.authorSelvakumar, Ren_US
dc.contributor.authorKanagasabapathy, A Sen_US
dc.contributor.authorThomas, Ken_US
dc.contributor.authorLakshmi,en_US
dc.date.accessioned2009-05-28T13:41:49Z
dc.date.available2009-05-28T13:41:49Z
dc.date.issued1998-07-23en_US
dc.description.abstractThe role of acetylation in the antiglycating and anticataract effects of aspirin (ASA) is explored by comparing ASA's effects with that of sodium salicylate (SS), a nonacetyl analog of ASA, on cataract development in diabetic rats. Streptozocin diabetic rats were provided with either ASA or SS, orally, for 24 weeks. Appropriate drug controls, normal controls and diabetic controls were run in parallel. Periodic estimations of blood glucose, glycated hemoglobin and assessments of cataract progression were done. After 24 weeks lenses were removed, homogenised and separated into water soluble fraction and urea soluble fraction. The glycated lens proteins in each fraction was quantified. Results were analysed statistically and interpreted in relation to serum salicylate levels. Both ASA and SS did not influence blood glucose levels. In the untreated diabetic groups the onset and progression of cataract was quicker and complete within 16 weeks. Both ASA and SS delayed the onset and progression in diabetic rats, but ASA's effect was more pronounced than that of SS. The levels of glycated Hb and lens proteins in diabetic rats were significantly reduced by ASA and not by SS for the same serum salicylate levels. ASA's anticataract potential far exceeds that of SS and it is ASA, and not SS, that inhibits protein glycation. Thus the results favour the hypothesis that acetylation plays a major role in ASA's anticataract effect via inhibition of glycation.en_US
dc.description.affiliationChristian Medical College & Hospital, Vellore, India.en_US
dc.identifier.citationShastri GV, Thomas M, Victoria AJ, Selvakumar R, Kanagasabapathy AS, Thomas K, Lakshmi . Effect of aspirin and sodium salicylate on cataract development in diabetic rats. Indian Journal of Experimental Biology. 1998 Jul; 36(7): 651-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59748
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAspirin --therapeutic useen_US
dc.subject.meshCataract --drug therapyen_US
dc.subject.meshDiabetes Mellitus, Experimental --complicationsen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshDrug Evaluation, Preclinicalen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSodium Salicylate --therapeutic useen_US
dc.titleEffect of aspirin and sodium salicylate on cataract development in diabetic rats.en_US
dc.typeJournal Articleen_US
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