Estrogen reduced blood glucose in high fat-fed mice: An animal model of type 2 diabetes.
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Date
2007-05
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Abstract
Objective: This study aims to produce a mouse model of type 2 diabetes by using high fat diet. The C57BL/6J mouse strain can develop type 2 diabetes by putting on high fat diet.
Methods: A group of C57BL/6J male mice were fed with a high fat diet (53% energy by fat) while another group was fed with normal diet (4.5% energy by fat).
Results: At the 16th week of feeding study, the high fat-fed mice developed type 2 diabetes and had higher fat-pad weight than the normal diet-fed mice. However, plasma triglyceride (TG) levels of the two groups were not different. High fat-induced diabetic mice were administered 0.2 ตg/g body weight of 17-β estradiol for 2 weeks. Their fasting blood levels were reduced to become lesser than the levels in high-fat fed mice without estrogen. A trend of decrease in plasma TG level of 17β estradiol treated mice was observed.
Conclusion: This study demonstrated that high fat diet could induce type 2 diabetes in a mouse model and that estrogen could reduce the fasting blood glucose in these mice.
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Keywords
Blood glucose, C57BL/6J mice, estrogen, high fat diet, type 2 diabetes
Citation
Kooptiwut Suwattanee, Semprasert Namoiy, Onreabroi Smarn, Churintrapun Malika, Chearskul Supornpim. Estrogen reduced blood glucose in high fat-fed mice: An animal model of type 2 diabetes. Siriraj Medical Journal, 2007 May; 59(4): 164-167.