olf413 Gene Controls Taste Recognition, Preference and Feeding Activity in Drosophila melanogaster

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dc.contributor.authorRamya, Ren_US
dc.contributor.authorShyamala, B. V.en_US
dc.date.accessioned2023-07-14T08:03:57Z
dc.date.available2023-07-14T08:03:57Z
dc.date.issued2023-05
dc.description.abstractRecognition and responsiveness to food taste becomes a crucial event in foraging and feeding behaviour of an organism. Adjusting the feeding behaviour through a sophisticated and robust taste system is critical to fulfil their nutritional needs and facilitate its survival in environment. Palatability of food sources depends on the sensory and motor cues provided by the brain, in co-ordination with the other body systems to enable decisive feeding. Drosophila melanogaster is an apt model organism to decipher these behavioural paradigms. Octopamine a neurotransmitter, is required in regulation of feeding behavioural responses. olf413, a paralogue of TH, is a gene predicted for its involvement in octopamine biosynthesis. The biological function of this gene is yet to be unravelled. Here we propose this gene function in taste recognition, food preference and feeding activity. We test the olf413 loss of function mutants for food preference between two fruit extracts using CAFE and horizontal box methods. In our study we have used olf413 gene disruption strain, olf413MI02014 homozygous and in transheterozygous condition with another allele isolated in our lab, olf413SG1.1. The results show that olf413 mutants display a severe phenotype in feeding behaviour and there is an allele specific phenotypic distinction between the two strains. Thus implying that olf413 gene function is required for taste recognition, starvation driven initiation and execution of feeding behaviour of the flies.en_US
dc.identifier.affiliationsDevelopmental Genetics Laboratory, Department of Studies in Zoology, University of Mysore, Mysuru-570006, India.en_US
dc.identifier.citationRamya R., Shyamala B. V.. olf413 Gene Controls Taste Recognition, Preference and Feeding Activity in Drosophila melanogaster. Annual Research & Review in Biology. 2023 May; 38(5): 24-31en_US
dc.identifier.issn2347-565X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219412
dc.languageenen_US
dc.publisherSciencedomain Internationalen_US
dc.relation.issuenumber5en_US
dc.relation.volume38en_US
dc.source.urihttps://doi.org/10.9734/arrb/2023/v38i530585en_US
dc.subjectolf413en_US
dc.subjectDrosophila melanogasteren_US
dc.subjectT?Hen_US
dc.subjectfood preferenceen_US
dc.subjectstarvation driven feeding responseen_US
dc.subjectCAFEen_US
dc.subjecttaste responseen_US
dc.titleolf413 Gene Controls Taste Recognition, Preference and Feeding Activity in Drosophila melanogasteren_US
dc.typeJournal Articleen_US
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