Apo B/Apo A-I Ratio A Better Predictor of Coronary Artery Disease in Patients with or Without Type II Diabetes Mellitus.
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Date
2011-07
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Abstract
The increasing disease burden due to coronary artery disease (CAD) can be
minimized by an early detection using a valid risk factor. Aim of this study was to determine the
level of apolipoprotein AI(ApoAI), apolipoprotein B(ApoB) and ApoB/ApoAI ratio in CAD
patients with or without type II diabetes mellitus(DM) and to analyze whether these parameters can
be used as a more accurate lipid risk factor than the conventional ones. Fasting blood samples were
collected from angiographically determined coronary artery disease patients with or without type II
DM and control subjects. Serum total cholesterol (TC), triglycerides (TG),and high density
lipoprotein (HDL-C)were measured enzymatically ,low density lipoprotein (LDL-C) was determined
using Friedewald's formula ,Apo AI and Apo B were analyzed by immunoturbidimetric method.
Plasma values of total cholesterol, triglycerides (TG), low density lipoprotein (LDL) cholesterol,
were not significantly different in the groups with normal coronary arteries and CAD. Level of
ApoB was significantly higher and the level of Apo AI was significantly lower in CAD patients
when compared to normal coronary artery group. In the study, ratio of Apo B to Apo AI (Apo B/
Apo AI) was found to be markedly high in CAD patients ( p<0.001) when compared to the control .
As the ratio covers both atherogenic and antiatherogenic lipid risk factor, it can be used as a better
predictor than conventional risk factor.
Description
Keywords
Apolipoprotein AI, Apolipoprotein B, coronary artery disease (CAD), Diabetes Mellitus
Citation
Philip Sachu, Abraham Philips, Sheriff D S. Apo B/Apo A-I Ratio A Better Predictor of Coronary Artery Disease in Patients with or Without Type II Diabetes Mellitus. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Jul-Sept; 2(3): 153-158.