Correlation of phospholipid loss in goat whole blood with solvochromic properties of antiamebics like emetine, metronidazole and diloxanide furoate.

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dc.contributor.authorSengupta, Men_US
dc.contributor.authorDutta, Hen_US
dc.contributor.authorPal, D Ken_US
dc.contributor.authorDe, A Uen_US
dc.contributor.authorSengupta, Cen_US
dc.date.accessioned2009-05-28T14:27:25Z
dc.date.available2009-05-28T14:27:25Z
dc.date.issued1993-01-01en_US
dc.description.abstractPhospholipid content of whole blood lipid decreases significantly when goat blood is incubated for different length of time with different amebicidal agents (e.g., emetine, metronidazole and diloxanide furoate). The plots of relative per cent phosphate loss against incubation period show biphasic nature and suggest that the rates of phospholipid loss bears some relation with the drug's lipophilicity (log P in 1 octanol/water system). The absolute phospholipid loss seems to be governed by the drug's aquasolubility. Implication of these finding were discussed in terms of their clinical profiles assuming that the loss of phospholipid is due to drug's binding with the phospholipid layer in amebic cyst-coat, being the first step which may trigger a chain of events leading to the onset of drug action.en_US
dc.description.affiliationDepartment of Pharmaceutical Technology, Jadavpur University, Calcutta, India.en_US
dc.identifier.citationSengupta M, Dutta H, Pal DK, De AU, Sengupta C. Correlation of phospholipid loss in goat whole blood with solvochromic properties of antiamebics like emetine, metronidazole and diloxanide furoate. Indian Journal of Experimental Biology. 1993 Jan; 31(1): 21-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60732
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAmebicides --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEmetine --pharmacologyen_US
dc.subject.meshFurans --pharmacologyen_US
dc.subject.meshGoatsen_US
dc.subject.meshMetronidazole --pharmacologyen_US
dc.subject.meshPhospholipids --blooden_US
dc.subject.meshSolubilityen_US
dc.titleCorrelation of phospholipid loss in goat whole blood with solvochromic properties of antiamebics like emetine, metronidazole and diloxanide furoate.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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