Healing-promoting action of rhinax with dual action on chronic gastric and duodenal ulcers induced by acetic acid in rats.

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dc.contributor.authorDhuley, J Nen_US
dc.date.accessioned2003-02-12en_US
dc.date.accessioned2009-05-27T04:14:45Z
dc.date.available2003-02-12en_US
dc.date.available2009-05-27T04:14:45Z
dc.date.issued2003-02-12en_US
dc.description.abstractHealing promoting actions of Rhinax, a multiconstituent herbal preparation, was investigated in chronic gastric and duodenal ulcer models induced by acetic acid in rats and the effects were compared with those of famotidine by gross of histological evaluation. Rhinax markedly promoted the well balanced healing of gastric ulcer at oral does of 25-100 mg/kg x 2 /day, as evidenced by the reduction of ulcer, regeneration of mucosa and proliferation of connecitve tissue. Rhinax caused an increase in gastric mucosa secretion in all the regenerated mucosa around the gastric ulcers. Famotidine failed to promote the healing of gastric ulcers at 100 mg/kg x 2/ day p.o. Rhinax also significantly accelerated the healing of acetic acid -induced duodenal ulcers as well famotidine. These results indicate that Rhinax is characterised by a potent promoting action on the healing of chronic ulcers, suggesting that the increase in gastric mucus secretion might be associated with the antiulcer action of Rhinax in rats.en_US
dc.description.affiliationPharmacology & Toxicology section, Research & Development Division, Hindustan Antibiotics Limited, Pimpri, Pune 411 018, India.en_US
dc.identifier.citationDhuley JN. Healing-promoting action of rhinax with dual action on chronic gastric and duodenal ulcers induced by acetic acid in rats. Hindustan Antibiotics Bulletin. 2003 Feb-2004 Nov; 45-46(1-4): 34-40en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/2369
dc.language.isoengen_US
dc.subject.meshAcetic Aciden_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Ulcer Agents --therapeutic useen_US
dc.subject.meshDuodenal Ulcer --chemically induceden_US
dc.subject.meshFamotidine --therapeutic useen_US
dc.subject.meshMaleen_US
dc.subject.meshPlant Extracts --therapeutic useen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshStomach Ulcer --chemically induceden_US
dc.titleHealing-promoting action of rhinax with dual action on chronic gastric and duodenal ulcers induced by acetic acid in rats.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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