Genetic variation of GSTM1, GSTT1 and GSTP1 genes in a South Indian population.

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dc.contributor.authorV, Vettriselvien_US
dc.contributor.authorK, Vijayalakshmien_US
dc.contributor.authorPaul, Solomon Fden_US
dc.contributor.authorP, Venkatachalamen_US
dc.date.accessioned2009-05-27T17:46:37Z
dc.date.available2009-05-27T17:46:37Z
dc.date.issued2006-04-15en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractThe glutathione S transferase (GST) family of enzymes play a vital role in the phase II biotransformation of environmental carcinogens, pollutants, drugs and other xenobiotics. GSTs are polymorphic and the polymorphisms in GST genes have been associated with cancer susceptibility and prognosis. Moreover, distinct ethnic differences have been observed in the type and frequency of GST gene polymorphisms. Hence, the present study was aimed to determine the frequencies of GSTM1, GSTT1 and GSTP1 polymorphisms in 255 healthy random volunteers from South India. The GSTM1 and GSTT1 genotypes were determined by PCR and GSTP1 by PCR-RFLP using peripheral blood DNA.The GSTM1 and GSTT1 null genotype frequencies were found to be 22.4% and 17.6% respectively. The GSTP1 allelic frequency was 0.78 for the Ile allele and 0.22 for the Val allele and the genotype frequency was 58.4% for Ile/Ile, 38.4% for Ile/Val, and 3.1% for Val/Val. Comparison of the frequencies of GST polymorphisms observed in the present study with other Indian and world populations revealed a distinctive nature of the South Indian population with respect to polymorphims at the GST gene loci. A better understanding of carcinogen metabolizing gene distribution should contribute to risk assessment of humans exposed to environmental carcinogens.en_US
dc.description.affiliationDepartment of Human Genetics, Sri Ramachandra Medical College and Research Institute 600116 Tamil Nadu, India.en_US
dc.identifier.citationV V, K V, Paul SF, P V. Genetic variation of GSTM1, GSTT1 and GSTP1 genes in a South Indian population. Asian Pacific Journal of Cancer Prevention. 2006 Apr-Jun; 7(2): 325-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37865
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshEthnic Groups --geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshGlutathione S-Transferase pi --geneticsen_US
dc.subject.meshGlutathione Transferase --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReference Valuesen_US
dc.titleGenetic variation of GSTM1, GSTT1 and GSTP1 genes in a South Indian population.en_US
dc.typeJournal Articleen_US
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