Co-infection of Malaria and Typhoid Fever in Feverish Patients in the Kumba Health District, Southwest Cameroon: Public Health Implications.

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dc.contributor.authorNdip, Lucy M
dc.contributor.authorEgbe, Franklyn N
dc.contributor.authorKimbi, Helen K
dc.contributor.authorNjom, Henry A
dc.contributor.authorNdip, Roland N
dc.date.accessioned2015-12-04T03:57:00Z
dc.date.available2015-12-04T03:57:00Z
dc.date.issued2015
dc.description.abstractAims: This study was aimed at generating updated baseline data on co-infection of malaria and typhoid fever and finding out the implications of these co-infections in disease severity. Study Design: The study was cross-sectional. Place and Duration of Study: The study was carried out in Kumba, Southwest Cameroon from May to July, 2010. Methodology: Venous blood was collected from 206 febrile patients of both sexes aged 4-80 years old at the Kumba District Hospital. Malaria parasite density and speciation were determined using Giemsa-stained thick and thin blood films respectively. Typhoid fever was diagnosed by isolation and characterisation of the aetiologic agent from stool samples in 178/206 patients. Antimicrobial susceptibility of recovered isolates was determined by the disc diffusion method. Anaemia status, Alanine aminotransferase (ALT) and Aspatate aminotransferase (AST) values were determined. Results: Overall malaria prevalence was 90.3% (186/206) while geometric mean parasite density (GMPD) was 866 (range: 40 – 64880) parasites/μL of blood. Plasmodium falciparum was the most prevalent Plasmodium species. Overall prevalence of typhoid fever was 7.9% (14/178) while malaria/typhoid fever co-infection rate was 6.74% (12). Of the 14 typhoidal Salmonella isolates recovered, 6 were identified as Salmonella typhi and 8 as S. paratyphi. The Salmonella isolates were all susceptible to ciprofloxacin and gentamycin. Patients co-infected with malaria/typhoid fever had a significantly higher (P = .007) GMPD (1203, range: 100-64880 parasites/μL) when compared to patients with mono-infections of malaria (774, range: 40-18660 parasites/μL). Abnormal ALT and anorexia prevalence values were significantly higher (P=.01 and P =.045 respectively) in patients with only typhoid fever than their counterparts. The values of anaemia and AST were comparable in all groups of patients. Conclusion: This study confirms that co-infections of malaria and typhoid fever are common and may exacerbate malaria intensity.en_US
dc.identifier.citationNdip Lucy M, Egbe Franklyn N, Kimbi Helen K, Njom Henry A, Ndip Roland N. Co-infection of Malaria and Typhoid Fever in Feverish Patients in the Kumba Health District, Southwest Cameroon: Public Health Implications. International Journal of TROPICAL DISEASE & Health. 2015; 9(4): 1-11.en_US
dc.identifier.issn2278–1005
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/167041
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/10025en_US
dc.subjectMalariaen_US
dc.subjecttyphoid feveren_US
dc.subjectco-infectionen_US
dc.subjectdiagnosisen_US
dc.subjectprevalenceen_US
dc.subjectseverityen_US
dc.subjectCameroonen_US
dc.titleCo-infection of Malaria and Typhoid Fever in Feverish Patients in the Kumba Health District, Southwest Cameroon: Public Health Implications.en_US
dc.typeArticleen_US
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