Nephroprotective Activity Of Plumeria Rubra Against Cisplatin Induced Nephrotoxicity In Experimental Rats

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dc.contributor.authorYadav, A. V.en_US
dc.contributor.authorUpasani, C. D.en_US
dc.date.accessioned2020-09-24T08:00:53Z
dc.date.available2020-09-24T08:00:53Z
dc.date.issued2019-04
dc.description.abstractObjective: The current study was designed to evaluate the protective effect of standardized hydroalcoholic extract of Plumeria rubra (HAEPR) against cisplatin-induced nephrotoxicity in Wistar rats.  Methods: HAEPR was administered orally at 3 dose levels (100,200,400 mg/kg). Vitamin E (250 mg/kg) was used as a Standard nephroprotective agent. The kidney function test (estimation of serum creatinine, albumin, blood urea nitrogen) oxidative stress study (estimation of superoxide dismutase, malondialdehyde activity) and histological examination of kidneys was conducted. Results: The efficacy of HAEPR was compared with Cisplatin (CP) treated group. Serum creatinine and BUN was significantly (p<0.01) elevated in CP-treated group compared to the control group. HAEPR (100,200 mg/kg) and Vitamin E (250 mg/kg) significantly (p<0.01) decreased the serum creatinine and BUN levels. CP treated group exhibited significant (p<0.01) decrease in albumin when compared to control. Significant (p<0.01) increase in the serum albumin level was found in HAEPR (100,200 mg/kg) and Vitamin E (250 mg/kg) compared to CP group. Significant (p<0.01) decrease in the activity of SOD was observed in the CP group as compared to control. HAEPR (100 and 200 mg/kg) and Vitamin E (250 mg/kg) significantly (p<0.01) increased SOD levels. HAEPR (400 mg/kg) significantly (p<0.05) increased SOD levels. HAEPR (100,200,400 mg/kg) significantly (p<0.01) decreased MDA levels as compared to CP group. Histopathological examination of the kidneys showed that HAEPR markedly ameliorated Cisplatin-induced renal tubular necrosis. An extract was found effective at all doses, although low dose (100 mg/kg) was found to be more effective and comparable with the standard group (Vitamin E 250 mg/kg).  Conclusion: Present investigation revealed that HAEPR resulted in attenuation of Cisplatin-induced renal damage in rats.en_US
dc.identifier.affiliationsDepartment of Pharmacology, SNJB’s Shriman Sureshdada Jain College of Pharmacy, Chandwad, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, SNJB’s Shriman Sureshdada Jain College of Pharmacy, Chandwad, Indiaen_US
dc.identifier.citationYadav A. V., Upasani C. D.. Nephroprotective Activity Of Plumeria Rubra Against Cisplatin Induced Nephrotoxicity In Experimental Rats. International Journal of Pharmacy and Pharmaceutical Sciences. 2019 Apr; 11(4): 108-113en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/205887
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber4en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2019v11i4.31561en_US
dc.subjectPlumeria rubraen_US
dc.subjectCisplatinen_US
dc.subjectNephrotoxicityen_US
dc.subjectCreatinineen_US
dc.subjectOxidative stressen_US
dc.titleNephroprotective Activity Of Plumeria Rubra Against Cisplatin Induced Nephrotoxicity In Experimental Ratsen_US
dc.typeJournal Articleen_US
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