Carotid Intima Medial Thickness as A Surrogate Marker for Systemic Atherosclerosis in Type 2 Diabetes Mellitus

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dc.contributor.authorAcharyya, Malayen_US
dc.contributor.authorHaldar, Swapan Kumaren_US
dc.date.accessioned2019-11-16T07:24:08Z
dc.date.available2019-11-16T07:24:08Z
dc.date.issued2019-04
dc.description.abstractBackground: The objective was to measure the correlation between carotid intima medial thickness (CIMT) with duration of type 2 diabetes mellitus (DM) and its correlation with biochemical markers and body mass index (BMI). Methods: The study was conducted in a tertiary care hospital in Kolkata. Total 100 patients were selected randomly who met the inclusion criteria. Among total patients, 20 cases were newly detected type 2 DM patients and 80 were cases of established diabetes, with different duration of DM. CIMT was measured by carotid artery ultrasonography using an echo tomography system having midfrequency of 7.5MhZ and detection limit of 0.1mm. Duration of diabetes was measured as present age minus age of detection of DM. BMI was measured by the guideline of WHO. The parameters were estimated such as microalbuminuria by radioimmunoassay, fasting blood sugar (FBS) level and HbA1C by HPLC method, uric acid by uricase method. Data was collected using a predetermined proforma and statistical analyses were done. Results: Duration of DM was positively correlated with CIMT and association was statistically significant (P<0.02). There was increase in CCA-IMT and ICA-IMT across increasing level of FBS and HbA1c (P<0.01). Microalbuminuria is considered a novel atherosclerotic risk factor, was found significantly associated with mean CIMT (P<0.001). CIMT was also significantly associated with HbA1C (P<0.001). The significantly (P<0.01) increased level of uric acid indicated higher carotid plaque. Conclusion: CIMT is an objective measure of subclinical atherosclerosis, which is a non- invasive, less expensive, duration and reproducible way of demonstrating subclinical atherosclerosis. Thus, it can serve as a window for atherosclerosis status in other major arteries like coronary artery and cerebral arteries. The CIMT is closely associated with several markers viz. uric acid, blood sugar, HbA1c, albumin and BMI during the progression of type 2 DM.en_US
dc.identifier.affiliationsDepartment of cardiology Midnapur Medical College and Hospital Vidyasagar Road, Midnapur – 721101, West Bengal, India.en_US
dc.identifier.affiliationsDepartment of cardiology Nil Ratan Sircar Medical College and Hospital 138, AJC Bose Road, Kolkata - 700014, India.en_US
dc.identifier.citationAcharyya Malay, Haldar Swapan Kumar. Carotid Intima Medial Thickness as A Surrogate Marker for Systemic Atherosclerosis in Type 2 Diabetes Mellitus. International Archives of BioMedical and Clinical Research. 2019 Apr-Jun; 5(2): 23-27en_US
dc.identifier.issn2454-9894
dc.identifier.issn2454-9886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/184187
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber2en_US
dc.relation.volume5en_US
dc.source.urihttps://doi.org/10.21276/iabcr.2019.5.2.08en_US
dc.subjectCarotid intima medial thicknessen_US
dc.subjectDuration of diabetes mellitusen_US
dc.subjectAlbuminuriaen_US
dc.subjectBlood sugar levelen_US
dc.subjectBMIen_US
dc.subjectUric aciden_US
dc.titleCarotid Intima Medial Thickness as A Surrogate Marker for Systemic Atherosclerosis in Type 2 Diabetes Mellitusen_US
dc.typeJournal Articleen_US
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