Broad spectrum antibacterial activity of granaticinic acid, isolated from Streptomyces thermoviolaceus NT1; an endophyte in Catharanthus roseus (L.) G. Don.

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dc.contributor.authorRoy, Sudipta
dc.contributor.authorBanerjee, Debdulal
dc.date.accessioned2015-11-24T10:13:37Z
dc.date.available2015-11-24T10:13:37Z
dc.date.issued2015-07
dc.description.abstractSearching for endophytic actinomycetes, strain NT1 was isolated from surface sterilized stem of Catharanthus roseus (L.) G. Don collected from Paschim Medinipur, India. The strain was identified as Streptomyces thermoviolaceus NT1 on the basis of morphological, biochemical and 16s rDNA based phylogenetic analysis. It showed potential antagonism against several Gram positive and Gram negative bacterial pathogens along with drug resistant Staphylococcus aureus. Maximum antibacterial production was obtained in ISP2 media at pH 7.2, 35 °C for 10 days. The active antibacterial substance was purified by Silica gel column chromatography and activity guided TLC. IR and NMR analysis identified the active compound as granaticinic acid of m/z 463.26 [M+H]. These results suggest that the antimicrobial produced by the isolated endophytic strain will be useful in near future.en_US
dc.identifier.citationRoy Sudipta, Banerjee Debdulal. Broad spectrum antibacterial activity of granaticinic acid, isolated from Streptomyces thermoviolaceus NT1; an endophyte in Catharanthus roseus (L.) G. Don. Journal of Applied Pharmaceutical Science. 2015 July; 5(7): 6-11.en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/166202
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/past-articles.php?issueid=61#en_US
dc.subjectEndophyteen_US
dc.subjectStreptomyces thermoviolaceusen_US
dc.subjectgranaticinic aciden_US
dc.subjectantibacterialen_US
dc.subjectdrug resistanceen_US
dc.titleBroad spectrum antibacterial activity of granaticinic acid, isolated from Streptomyces thermoviolaceus NT1; an endophyte in Catharanthus roseus (L.) G. Don.en_US
dc.typeArticleen_US
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