Phytochemical and Antioxidant Evaluations of Chromolaena odorata and Huntaria umbellata

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dc.contributor.authorEze, ILen_US
dc.contributor.authorOnyegbule, FAen_US
dc.contributor.authorEzugwu, COen_US
dc.contributor.authorChibuzor, JVen_US
dc.contributor.authorAziakpono, OM.en_US
dc.date.accessioned2025-05-12T10:23:17Z
dc.date.available2025-05-12T10:23:17Z
dc.date.issued2024-12
dc.description.abstractWith the increasing demand for herbal medicine, it is imperative to validate the presence of the most anticipated antioxidants present in plants, which motivated the aim of this study. Hence, the efficacy of Chromolaena odorata and Hunteria umbellata were validated. Natural antioxidants in medicinal plants, such as polyphenols and flavonoids, mitigate oxidative stress and serve as alternative treatments for various diseases. We obtained crude extracts through cold maceration and qualitative and quantitative phytochemical screenings for alkaloids, flavonoids, tannins, and saponins. Antioxidant profiles were assessed using DPPH and FRAP assays for In vitro and MDA, SOD, and CAT assays for In vivo. The liquid (ethanol) extracts from these plants were tested to confirm the presence of alkaloids, flavonoids, saponins, tannins, and glycosides in the ethanol extracts of Chromolaena odorata leaves and Hunteria umbellata seeds. The decreasing effect of DPPH experienced in both plant extracts validates the presence of free radical scavenging activities and ferric-reducing antioxidant potential in a concentration-dependent manner. Chromolaena odorata demonstrated superior inhibition in both DPPH (88.89 ± 0.26%) and FRAP (90.16 ± 0.76%) assays compared to Hunteria umbellata. In vivo studies showed dose-dependent antioxidant effects, with 500 mg/kg of Chromolaena odorata exhibiting the best results across MDA, SOD, and CAT indices. This study concludes that Chromolaena odorata leaves possess higher antioxidant activity and phytochemical content than Hunteria umbellata seeds, supporting their potential use in antioxidant therapies.en_US
dc.identifier.affiliationsDepartment of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University Awka, Nigeriaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University Awka, Nigeriaen_US
dc.identifier.affiliationsDepartment of Pharmacognosy and Environmental Medicine, University of Nigeria Nsukka, Nigeriaen_US
dc.identifier.affiliationsDepartment of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University Awka, Nigeriaen_US
dc.identifier.affiliationsDepartment of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Federal University Oye-Ekiti, Ekiti State, Nigeria.en_US
dc.identifier.citationEze IL, Onyegbule FA, Ezugwu CO, Chibuzor JV, Aziakpono OM.. Phytochemical and Antioxidant Evaluations of Chromolaena odorata and Huntaria umbellata . Journal of Pharmaceutical Research International. 2024 Dec; 36(12): 213-224en_US
dc.identifier.issn2456-9119
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247686
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber12en_US
dc.relation.volume36en_US
dc.source.urihttps://doi.org/10.9734/jpri/2024/v36i127641en_US
dc.subjectPhytochemicalen_US
dc.subjectantioxidanten_US
dc.subjectChromolaena odorataen_US
dc.subjectHunteria umbellateen_US
dc.subjectIn vitroen_US
dc.subjectIn vivoen_US
dc.subjectacute toxicityen_US
dc.subjectoxidative stressen_US
dc.titlePhytochemical and Antioxidant Evaluations of Chromolaena odorata and Huntaria umbellataen_US
dc.typeJournal Articleen_US
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