Effect of Enalapril on Glomerular Filtration Rate and Proteinuria in Children with Chronic Kidney Disease: A Randomized Controlled Trial.

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dc.contributor.authorHari, Pankaj
dc.contributor.authorSahu, Jitender
dc.contributor.authorSinha, Aditi
dc.contributor.authorPandey, Ravinder Mohan
dc.contributor.authorBal, Chandra Shekhar
dc.contributor.authorBagga, Arvind
dc.date.accessioned2016-01-06T09:20:47Z
dc.date.available2016-01-06T09:20:47Z
dc.date.issued2013-10
dc.description.abstractObjective: To evaluate the efficacy of enalapril treatment on decline in glomerular filtration rate and reduction in proteinuria in children with chronic kidney disease (CKD). Design: Open-label, randomized controlled trial. Setting: Pediatric nephrology clinic at a tertiary-care referral hospital. Intervention: Children with GFR between 15-60 mL/min/1.73 m2 were randomized to receive either enalapril at 0.4 mg/kg /day or no enalapril for 1 year. Outcome measures: Change in GFR using 99mTc-DTPA and urine protein to creatinine ratio. Secondary outcomes included occurrence of composite outcome (30% decline in GFR or end stage renal disease) and systolic and diastolic blood pressure SDS during the study period. Results: 41 children were randomized into two groups; 20 received enalapril while 21 did not receive enalapril. During 1 year, GFR decline was not different in the two groups (regression coefficient (r) 0.40, 95% CI -4.29 to 5.09, P=0.86). The mean proteinuria reduction was 65% in the enalapril group, significantly higher than control group. The difference was significant even after adjustment for blood pressure was 198.5 (CI 97.5, 299.3; P<0.001). 3 (17.6%) patients in enalapril and 7 (36.8%) in nonenalapril group attained the composite outcome. Conclusions: Enalapril is effective in reducing proteinuria in children with CKD and might be renoprotective in proteinuric CKD.en_US
dc.identifier.citationHari Pankaj, Sahu Jitender, Sinha Aditi, Pandey Ravinder Mohan, Bal Chandra Shekhar, Bagga Arvind. Effect of Enalapril on Glomerular Filtration Rate and Proteinuria in Children with Chronic Kidney Disease: A Randomized Controlled Trial. Indian Pediatrics. 2013 October; 50(10): 923-928.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/169999
dc.language.isoenen_US
dc.source.urihttps://www.indianpediatrics.net/oct2013/oct-923-928.htmen_US
dc.subjectChronic kidney diseaseen_US
dc.subjectEnalaprilen_US
dc.subjectGFRen_US
dc.subjectProteinuriaen_US
dc.titleEffect of Enalapril on Glomerular Filtration Rate and Proteinuria in Children with Chronic Kidney Disease: A Randomized Controlled Trial.en_US
dc.typeArticleen_US
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