A study of coagulation profile in preeclampsia compared to normal pregnancy

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dc.contributor.authorTasleem, Sen_US
dc.contributor.authorAli, SIen_US
dc.contributor.authorBegum, MN.en_US
dc.date.accessioned2023-06-27T06:39:34Z
dc.date.available2023-06-27T06:39:34Z
dc.date.issued2022-12
dc.description.abstractBackground: Preeclampsia is a condition of unknown etiology of multiorgan disease and is distinguished by a raised blood pressure (B.P. >140/90 mmHg) and proteinuria (>300 mg per 24 h) and/or edema following 20 weeks of pregnancy. Aims and Objectives: The study was conducted to differentiate coagulation variables between normotensives and preeclamptic patients. Materials and Methods: Prior consent was obtained from Institutional Ethics Committee. Patients diagnosed with preeclampsia aged between 20 and 35 years were incorporated into the study. Patients with a previous history of hypertension, thyroid disease, and diabetes were excluded from the study. Age-matched controls were taken and analyzed. Data collection done by (i) BP measured in supine posture; (ii) bleeding time (B.T) estimation – by Duke’s method; (iii) clotting time (C.T) estimation – by Wright’s capillary tube method; (iv) platelet count (P.C) estimation – by automated hematology analyzer; and (v) prothrombin time (P.T) and activated partial thromboplastin time (APTT) – estimation by semi-automated analyzer. Results: The study revealed a significant interrelation between P.C and B.T when preeclampsia patients were correlated with normotensives patients while P.T, APTT, and C.T were insignificant statistically. Conclusion: A statistically significant change was observed proposing parameters derangement as the disease becomes more progressive.en_US
dc.identifier.affiliationsDepartment of Physiology, Malla Reddy Institute of Medical Sciences, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of Physiology, Government Medical College and Hospital, Nagarkurnool, Telangana, Indiaen_US
dc.identifier.citationTasleem S, Ali SI, Begum MN.. A study of coagulation profile in preeclampsia compared to normal pregnancy. National Journal of Physiology, Pharmacy and Pharmacology. 2022 Dec; 12(12): 2037-2041en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/217823
dc.languageenen_US
dc.publisherMrs Dipika Charan of MedScience (India) Publicationsen_US
dc.relation.issuenumber12en_US
dc.relation.volume12en_US
dc.source.urihttps://dx.doi.org/10.5455/njppp.2022.12.04165202213042022en_US
dc.subjectPreeclampsiaen_US
dc.subjectPlatelet Counten_US
dc.subjectBleeding Timeen_US
dc.subjectClotting Timeen_US
dc.subjectProthrombin Timeen_US
dc.subjectActivated Partial Thromboplastin Timeen_US
dc.titleA study of coagulation profile in preeclampsia compared to normal pregnancyen_US
dc.typeJournal Articleen_US
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