A study of coagulation profile in preeclampsia compared to normal pregnancy
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Date
2022-12
Authors
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Volume Title
Publisher
Mrs Dipika Charan of MedScience (India) Publications
Abstract
Background: Preeclampsia is a condition of unknown etiology of multiorgan disease and is distinguished by a raised blood pressure (B.P. >140/90 mmHg) and proteinuria (>300 mg per 24 h) and/or edema following 20 weeks of pregnancy. Aims and Objectives: The study was conducted to differentiate coagulation variables between normotensives and preeclamptic patients. Materials and Methods: Prior consent was obtained from Institutional Ethics Committee. Patients diagnosed with preeclampsia aged between 20 and 35 years were incorporated into the study. Patients with a previous history of hypertension, thyroid disease, and diabetes were excluded from the study. Age-matched controls were taken and analyzed. Data collection done by (i) BP measured in supine posture; (ii) bleeding time (B.T) estimation – by Duke’s method; (iii) clotting time (C.T) estimation – by Wright’s capillary tube method; (iv) platelet count (P.C) estimation – by automated hematology analyzer; and (v) prothrombin time (P.T) and activated partial thromboplastin time (APTT) – estimation by semi-automated analyzer. Results: The study revealed a significant interrelation between P.C and B.T when preeclampsia patients were correlated with normotensives patients while P.T, APTT, and C.T were insignificant statistically. Conclusion: A statistically significant change was observed proposing parameters derangement as the disease becomes more progressive.
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Keywords
Preeclampsia, Platelet Count, Bleeding Time, Clotting Time, Prothrombin Time, Activated Partial Thromboplastin Time
Citation
Tasleem S, Ali SI, Begum MN.. A study of coagulation profile in preeclampsia compared to normal pregnancy. National Journal of Physiology, Pharmacy and Pharmacology. 2022 Dec; 12(12): 2037-2041