Extrapolated response dose as a potential tool in radiotherapy and chemo-radiotherapy of head and neck cancers.

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dc.contributor.authorHema, Ven_US
dc.contributor.authorSupe, S Sen_US
dc.contributor.authorKannan, Ven_US
dc.contributor.authorDoval, D Cen_US
dc.contributor.authorAnantha, Nen_US
dc.contributor.authorSupe, S Jen_US
dc.date.accessioned2009-05-28T11:55:30Z
dc.date.available2009-05-28T11:55:30Z
dc.date.issued1996-09-01en_US
dc.description.abstractAn analysis of head and neck cancer patients treated by radiotherapy (RT) alone (114 patients) and by chemo-radiotherapy (RT + CT) (115 patients) was carried out; the doses varied from 40-77 Gy and 35-71 Gy in RT and RT + CT groups respectively. The chemotherapy (CT) (induction/concurrent) drugs used were 5-FU, cisplatin, methotrexate either single or in combination. Extrapolated response dose values were evaluated with alpha/beta values of 10, 2.5 and 6 Gy for acute, late complications and tumour response, respectively. Dose enhancement factor (DEF) and Therapeutic gain factor (TGF) values were evaluated on the basis of ERD for patients receiving 5-FU RTCT (72 patients). ERD vs late complication rate and response rate curves were drawn for RT, RT + CT (< 7 cycles), RT + CT (> 6 cycles) and RT + CT (cumulative). DEF values for response rate were 0.95, 0.95 and 0.82 for the three RT + CT groups respectively. Similarly DEF values for late complication rate were evaluated as 0.87, 0.93 and 0.88. TGF values for RT + CT were 1.09, 1.02 and 0.93. TGF values indicated lack of significant influence of CT on clinical outcome. The correlation of ERD with late complication, response and status at last follow up (NED) was statistically significant for both groups (P < 0.01). ERD did not correlated with acute complication in RT group (P > 0.01). From the present analysis, in RT + CT treatments of head and neck cancers, an ERD value of 69 Gy is suggested as the limit for an acceptable 5% late complication rate.en_US
dc.description.affiliationKidwai Memorial Institute of Oncology, Bangalore, India.en_US
dc.identifier.citationHema V, Supe SS, Kannan V, Doval DC, Anantha N, Supe SJ. Extrapolated response dose as a potential tool in radiotherapy and chemo-radiotherapy of head and neck cancers. Indian Journal of Experimental Biology. 1996 Sep; 34(9): 874-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/57386
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshHead and Neck Neoplasms --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshRadiotherapy Dosageen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleExtrapolated response dose as a potential tool in radiotherapy and chemo-radiotherapy of head and neck cancers.en_US
dc.typeJournal Articleen_US
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